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How to get fromSouth Carolina to Florida Keysby taxi, plane, train, bus, car, or shuttle

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There are 7 ways to get from South Carolina to Florida Keys by taxi, plane, train, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Charlotte Douglas International Airport, fly to Key West International Airport

    best
    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane plane CLT - EYW
    5h 45m
    $218–530

  2. Drive  726.2 mi

    cheapest
    1. Drive from Charleston to Florida Keyscar car 726.2 mi
    12h 52m
    $120–174

  3. Train, bus

    1. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train Silver Meteor
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    20h 56m
    $408–631

  4. Drive, bus, taxi, train

    1. Drive from Charleston to Sonic at Walmartcar car
    2. Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus bus 302
    3. Take the taxi from Bluffton Transfer Center to Savannah Stationtaxi taxi
    4. Take the train from Savannah Station to Jacksonvilletrain train
    5. Take the bus from Jacksonville to Miami Airport Stationbus bus
    6. Take the bus from Miami Airport Station to Big Pine Keybus bus
    22h 51m

  5. Fly Greenville–Spartanburg International Airport to Key West International Airport

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    6h 48m
    $173–452

  6. Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane plane GSP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 41m
    $248–552

  7. Fly Charleston International Airport to Key West International Airport

    1. Fly from Charleston International Airport (CHS) to Key West International Airport (EYW)plane plane CHS - EYW
    8h 41m
    $136–428

Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW) flights

Calendar60Weekly Planes
Duration4h 8mAverage Duration
Ticket$63Cheapest Price
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Comparing Your Travel Options

Map of how to get from South Carolina to Florida Keys.ExpandLaunch map view
  • Distance: 787.2 mi
  • Duration: 5h 45m

What companies run services between South Carolina, USA and Florida Keys, FL, USA?

Allegiant Air, American Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 4 hours.

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