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How to get fromSouth Carolina to Florida Keysby taxi, plane, train, bus, car, or shuttle

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There are 7 ways to get from South Carolina to Florida Keys by taxi, plane, train, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Charlotte Douglas International Airport, fly to Key West International Airport

    best
    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane plane CLT - EYW
    5h 39m
    $238–600

  2. Drive 726.2 mi

    cheapest
    1. Drive from Charleston to Florida Keyscar car 726.2 mi
    12h 52m
    $133–192

  3. Train, bus

    1. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train Silver Meteor
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    20h 56m
    $266–516

  4. Drive, bus

    1. Drive from Charleston to Sonic at Walmartcar car
    2. Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus bus 302
    3. Take the bus from Savannah Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    21h 19m

  5. Taxi to Asheville Regional Airport, fly to Key West International Airport

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    5h 56m
    $280–588

  6. Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane plane GSP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 45m
    $278–682

  7. Fly Charleston International Airport to Key West International Airport

    1. Fly from Charleston International Airport (CHS) to Key West International Airport (EYW)plane plane CHS - EYW
    8h 43m
    $351–598

Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW) flights

Calendar49Weekly Planes
Duration3h 59mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from South Carolina to Florida Keys.ExpandLaunch map view
  • Distance: 787.1 mi
  • Duration: 5h 39m

What companies run services between South Carolina, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Charleston International Airport (CHS) to Key West International Airport (EYW) 5 times a day.

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