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How to get fromSouth Carolina to Iowaby taxi, plane, train, bus, or car

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There are 9 ways to get from South Carolina to Iowa by taxi, plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Charlotte Douglas International Airport, fly to Des Moines

    best
    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    3h 12m
    $184–569

  2. Fly Greenville–Spartanburg International Airport to Quad City International Airport

    cheapest
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Quad City International Airport (MLI)plane plane GSP - MLI
    6h 30m
    $123–500

  3. Train, bus

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    38h 47m
    $419–966

  4. Drive, bus, taxi, train via Atlanta

    1. Drive from Charleston to Sonic at Walmartcar car
    2. Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus bus 302
    3. Take the taxi from Bluffton Transfer Center to Savannah Stationtaxi taxi
    4. Take the train from Savannah Station to Fayetteville Amtrak Stationtrain train
    5. Take the bus from Fayetteville Bus Station to Atlanta Bus Stationbus bus
    6. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus
    7. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    40h 28m

  5. Drive  1,160.5 mi

    1. Drive from Charleston to Des Moinescar car 1,160.5 mi
    20h 43m
    $212–306

  6. Taxi to Charlotte Douglas International Airport, fly to The Eastern Iowa Airport

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to The Eastern Iowa Airport (CID)plane plane CLT - CID
    3h 10m
    $201–576

  7. Taxi to Charlotte Douglas International Airport, fly to Omaha

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Omaha (OMA)plane plane CLT - OMA
    3h 32m
    $216–726

  8. Taxi to Charlotte Douglas International Airport, fly to Quad City International Airport

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Quad City International Airport (MLI)plane plane CLT - MLI
    4h 27m
    $158–518

  9. Drive, bus, taxi, train

    1. Drive from Charleston to Sonic at Walmartcar car
    2. Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus bus 302
    3. Take the taxi from Bluffton Transfer Center to Savannah Stationtaxi taxi
    4. Take the train from Savannah Station to Chicago Union Stationtrain train
    5. Take the bus from Chicago Bus Station to Des Moinesbus bus
    43h 36m

Charlotte Douglas International Airport (CLT) to Des Moines (DSM) flights

Calendar84Weekly Planes
Duration4h 21mAverage Duration
Ticket$85Cheapest Price
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Comparing Your Travel Options

Map of how to get from South Carolina to Iowa.ExpandLaunch map view
  • Distance: 847.2 mi
  • Duration: 3h 12m

What companies run services between South Carolina, USA and Iowa, USA?

Delta, United Airlines, and American Airlines fly from Greenville–Spartanburg International Airport (GSP) to Quad City International Airport (MLI) every 2 hours.

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