There are 10 ways to get from South Carolina to Key Largo by plane, shuttle, train, bus, car, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle
best- Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane GSP - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
4h 29m$221–638Drive 644.5 mi
cheapest- Drive from Charleston to Key Largocar 644.5 mi
10h 58m$118–170Train, bus
- Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain Silver Meteor
- Take the bus from Miami Airport Station to Key Largo Bus Stopbus Greyhound US0720s
17h 6m$213–438Drive, bus, taxi, train via Jacksonville
- Drive from Charleston to Sonic at Walmartcar
- Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus 302
- Take the taxi from Bluffton Transfer Center to Savannah Stationtaxi
- Take the train from Savannah Station to Jacksonvilletrain
- Take the bus from Jacksonville to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Key Largo Bus Stopbus
19h 46mTaxi to Charlotte Douglas International Airport, fly to Miami International Airport, shuttle
- Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi
- Fly from Charlotte Douglas International Airport (CLT) to Miami International Airport (MIA)plane CLT - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
4h 51m$311–606Fly Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport, shuttle
- Fly from Greenville–Spartanburg International Airport (GSP) to Fort Lauderdale–Hollywood International Airport (FLL)plane GSP - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FL
5h 1m$291–688Taxi to Charlotte Douglas International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle
- Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi
- Fly from Charlotte Douglas International Airport (CLT) to Fort Lauderdale–Hollywood International Airport (FLL)plane CLT - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FL
5h 17m$281–596Fly Charleston International Airport to Miami International Airport, shuttle
- Fly from Charleston International Airport (CHS) to Miami International Airport (MIA)plane CHS - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
6h 7m$594–1,134Fly Charleston International Airport to Fort Lauderdale–Hollywood International Airport, shuttle
- Fly from Charleston International Airport (CHS) to Fort Lauderdale–Hollywood International Airport (FLL)plane CHS - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FL
6h 30m$524–1,254Drive, bus, taxi, train
- Drive from Charleston to Sonic at Walmartcar
- Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus 302
- Take the taxi from Bluffton Transfer Center to Savannah Stationtaxi
- Take the train from Savannah Station to Miami Amtrak Stationtrain
- Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus 301
19h 44m
Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA) flights
Questions & Answers
The cheapest way to get from South Carolina to Key Largo is to drive which costs $110 - $170 and takes 10h 58m.
The fastest way to get from South Carolina to Key Largo is to fly and shuttle which takes 4h 29m and costs $220 - $650.
The distance between South Carolina and Key Largo is 714 miles. The road distance is 648.2 miles.
The best way to get from South Carolina to Key Largo without a car is to train and bus which takes 17h 6m and costs $210 - $440.
It takes approximately 4h 29m to get from South Carolina to Key Largo, including transfers.
Yes, the driving distance between South Carolina to Key Largo is 648 miles. It takes approximately 10h 58m to drive from South Carolina to Key Largo.
There are 341+ hotels available in Key Largo.
What companies run services between South Carolina, USA and Key Largo, FL, USA?
There is no direct connection from South Carolina to Key Largo. However, you can take the taxi to Greenville–Spartanburg International Airport (GSP) airport, fly to Miami International Airport (MIA), walk to Miami, FL - International Airport, then take the shuttle to Key Largo, FL. Alternatively, you can take a vehicle from Charleston to Key Largo Bus Stop via Charleston Amtrak Station, Hollywood Amtrak Station, Hollywood Station, Miami, Airport Intermodal Station, and Miami Airport Station in around 17h 6m.
- Website
- aa.com
Flights from Greenville–Spartanburg International Airport to Miami International Airport
- Ave. Duration
- 1h 56m
- When
- Every day
- Estimated price
- $80–460
Flights from Greenville–Spartanburg International Airport to Miami International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $90–480
Flights from Charlotte Douglas International Airport to Miami International Airport
- Ave. Duration
- 2h 6m
- When
- Every day
- Estimated price
- $80–440
Flights from Charlotte Douglas International Airport to Miami International Airport via Charleston International Airport
- Ave. Duration
- 3h 45m
- When
- Thursday and Sunday
- Estimated price
- $80–440
Flights from Charlotte Douglas International Airport to Miami International Airport via Greenville–Spartanburg International Airport
- Ave. Duration
- 3h 52m
- When
- Friday
- Estimated price
- $85–450
Flights from Charlotte Douglas International Airport to Miami International Airport via Jacksonville
- Ave. Duration
- 4h 12m
- When
- Saturday, Monday, Tuesday, Wednesday, and Friday
- Estimated price
- $80–440
Flights from Charlotte Douglas International Airport to Miami International Airport via Tampa
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $80–450
Flights from Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $90–500
Flights from Charlotte Douglas International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 59m
- When
- Every day
- Estimated price
- $80–450
Flights from Charleston International Airport to Miami International Airport
- Ave. Duration
- 1h 44m
- When
- Every day
- Estimated price
- $70–410
Flights from Charleston International Airport to Miami International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $95–490
Flights from Charleston International Airport to Fort Lauderdale–Hollywood International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $95–500
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Charleston Amtrak Station to Hollywood Amtrak Station
- Ave. Duration
- 13h 25m
- Frequency
- Once daily
- Estimated price
- $170–380
- Website
- Amtrak
Train from Savannah Station to Jacksonville
- Ave. Duration
- 2h 29m
- Frequency
- Twice daily
- Estimated price
- $35–90
- Website
- Amtrak
Train from Savannah Station to Miami Amtrak Station
- Ave. Duration
- 12h 10m
- Frequency
- Twice daily
- Estimated price
- $140–330
- Website
- Amtrak
- Phone
- +1 (305) 289-9997
- [email protected]
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a day
- Estimated price
- $100–130
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a day
- Estimated price
- $100–130
- Website
- Keys Shuttle
Shuttle from Fort Lauderdale, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $120–150
- Website
- Keys Shuttle
Shuttle from Fort Lauderdale, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $120–150
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a day
- Estimated price
- $100–130
- Website
- Keys Shuttle
Shuttle from Fort Lauderdale, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $120–150
- Website
- Keys Shuttle
- Ave. Duration
- 38 min
- Estimated price
- $80–140
Beeline Transportation
- Phone
- +1 843-683-1139
- Website
- taxihiltonhead.com
Hilton Head Taxi
- Phone
- +1 843-384-6408
Veteran's Cab Company
- Phone
- +1-803-327-4131
- Website
- rockhillcabs.com
Veteran's Cab Company
- Phone
- +1-803-327-4131
- Website
- rockhillcabs.com
Beeline Transportation
- Phone
- +1 843-683-1139
- Website
- taxihiltonhead.com
Hilton Head Taxi
- Phone
- +1 843-384-6408
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