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How to get fromSouth Carolina to Key Westby plane, train, bus, car, taxi, or shuttle

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There are 9 ways to get from South Carolina to Key West by plane, train, bus, car, taxi, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    4h 17m
    $122–441

  2. Fly from Columbia

    cheapest
    1. Fly from Columbia (CAE) to Key West International Airport (EYW)plane plane CAE - EYW
    5h 39m
    $72–354

  3. Train, bus

    1. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    21h 42m
    $408–631

  4. Drive, bus, taxi, train

    1. Drive from Charleston to Sonic at Walmartcar car
    2. Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus bus 302
    3. Take the taxi from Bluffton Transfer Center to Savannah Stationtaxi taxi
    4. Take the train from Savannah Station to Jacksonvilletrain train
    5. Take the bus from Jacksonville to Miami Airport Stationbus bus
    6. Take the bus from Miami Airport Station to Big Pine Keybus bus
    7. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    24h 23m

  5. Drive  741.6 mi

    1. Drive from Charleston to Key Westcar car 741.6 mi
    13h 14m
    $136–196

  6. Taxi to Charlotte Douglas International Airport, fly

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane plane CLT - EYW
    3h 2m
    $162–489

  7. Taxi to Asheville Regional Airport, fly

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    3h 6m
    $214–527

  8. Fly from Charleston International Airport

    1. Fly from Charleston International Airport (CHS) to Key West International Airport (EYW)plane plane CHS - EYW
    6h 7m
    $80–387

  9. Train, shuttle

    1. Take the train from Charleston Amtrak Station to Miami Amtrak Stationtrain train Silver Meteor
    2. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus To the Keys
    23h 28m
    $560–837

Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) flights

Calendar44Weekly Planes
Duration4h 40mAverage Duration
Ticket$70Cheapest Price
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Comparing Your Travel Options

Map of how to get from South Carolina to Key West.ExpandLaunch map view
  • Distance: 730.5 mi
  • Duration: 4h 17m

What companies run services between South Carolina, USA and Key West, FL, USA?

American Airlines, Allegiant Air, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 4 hours.

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