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How to get fromSouth Carolina to Knoxvilleby taxi, plane, train, bus, or car

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There are 5 ways to get from South Carolina to Knoxville by taxi, plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, fly

    best
    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    2h 7m
    $221–816

  2. Drive 372.7 mi

    cheapest
    1. Drive from Charleston to Knoxvillecar car 372.7 mi
    6h 22m
    $68–99

  3. Train, bus

    1. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Palmetto / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    27h 58m
    $399–679

  4. Drive, bus, taxi, train

    1. Drive from Charleston to Sonic at Walmartcar car
    2. Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus bus 302
    3. Take the taxi from Bluffton Transfer Center to Savannah Stationtaxi taxi
    4. Take the train from Savannah Station to Fayetteville Amtrak Stationtrain train
    5. Take the bus from Fayetteville Bus Station to New York City Chinatownbus bus
    6. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    37h 49m

  5. Train, bus via Farragut

    1. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Palmetto / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    30h 50m
    $417–737

Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS) flights

Calendar64Weekly Planes
Duration1h 38mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from South Carolina to Knoxville.ExpandLaunch map view
  • Distance: 216.1 mi
  • Duration: 2h 7m

What companies run services between South Carolina, USA and Knoxville, TN, USA?

There is no direct connection from South Carolina to Knoxville. However, you can take the taxi to Charlotte-Airport-CLT airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take a vehicle from Charleston to Knoxville via Charleston Amtrak Station, Ny Moynihan Train Hall At Penn Station, 34 St-Herald Sq, East Broadway, New York, NY, and Knoxville, TN in around 27h 58m.

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