Rome2Rio

How to get fromSouth Carolina to Lake Cityby train, bus, car, taxi, or plane

Find Transport to Lake City

See all options

There are 5 ways to get from South Carolina to Lake City by train, bus, car, taxi, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Charleston Amtrak Station to Jacksonvilletrain train Silver Meteor
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus Greyhound US0760S
    7h 36m
    $116–227

  2. Drive 291.9 mi

    cheapest
    1. Drive from Charleston to Lake Citycar car 291.9 mi
    5h 13m
    $54–77

  3. Taxi, fly to Jacksonville, bus

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Jacksonville (JAX)plane plane CLT - JAX
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    5h 30m
    $161–557

  4. Taxi, fly to Tallahassee, bus

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Tallahassee (TLH)plane plane CLT - TLH
    3. Take the bus from Tallahassee to Lake City Bus Stationbus bus
    5h 49m
    $204–704

  5. Taxi, fly to Gainesville Regional Airport, bus

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Gainesville Regional Airport (GNV)plane plane CLT - GNV
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    7h 3m
    $156–512

Charlotte Douglas International Airport (CLT) to Jacksonville (JAX) flights

Calendar53Weekly Planes
Duration1h 47mAverage Duration
Ticket$70Cheapest Price
See schedules

Questions & Answers

Map of how to get from South Carolina to Lake City.ExpandLaunch map view
  • Distance: 323.2 mi
  • Duration: 7h 36m

What companies run services between South Carolina, USA and Lake City, FL, USA?

There is no direct connection from South Carolina to Lake City. However, you can take the taxi to Charleston Amtrak Station, take the train to Jacksonville, walk to Amtrak Station, take the line 4 bus to JRTC Bay H, walk to Jacksonville, then take the bus to Lake City Bus Station. Alternatively, you can drive from Charleston to Lake City in around 5h 13m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound