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How to get fromSouth Carolina to Louisvilleby taxi, plane, bus (Greyhound, Flixbus, Amtrak), or car

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There are 6 ways to get from South Carolina to Louisville by taxi, plane, bus (Greyhound, Flixbus, Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Charlotte Douglas International Airport, fly to Louisville International Airport

    best
    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    3h 10m
    $172–699

  2. Drive 581.2 mi

    cheapest
    1. Drive from Charleston to Louisvillecar car 581.2 mi
    11h 17m
    $107–154

  3. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    24h 17m
    $139–269

  4. Fly Greenville–Spartanburg International Airport to Louisville International Airport

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF)plane plane GSP - SDF
    4h 35m
    $137–651

  5. Taxi to Charlotte Douglas International Airport, fly to Blue Grass Airport, drive

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)plane plane CLT - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    3h 20m
    $214–915

  6. Fly Charleston International Airport to Louisville International Airport

    1. Fly from Charleston International Airport (CHS) to Louisville International Airport (SDF)plane plane CHS - SDF
    5h 5m
    $345–407

South Carolina to Louisville by bus

Calendar14Weekly Buses
Duration24h 17mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from South Carolina to Louisville.ExpandLaunch map view
  • Distance: 368.8 mi
  • Duration: 3h 10m

What companies run services between South Carolina, USA and Louisville, KY, USA?

You can take a bus from Broad St / Meeting St to Louisville, KY via Spring St / Meeting St, Meeting St / Line St NB, N. Charleston SuperStop, North Charleston Transit Center, Charleston Bus Station, Atlanta Bus Station, and Nashville in around 24h 17m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) hourly.

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