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How to get fromSouth Carolina to St. Louisby taxi, plane, bus (Greyhound, Flixbus), car, bus, or train

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There are 6 ways to get from South Carolina to St. Louis by taxi, plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Charlotte Douglas International Airport, fly

    best
    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    3h 14m
    $204–799

  2. Fly from Charleston International Airport

    cheapest
    1. Fly from Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL)plane plane CHS - STL
    4h 50m
    $117–607

  3. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    26h 43m
    $159–314

  4. Drive 841 mi

    1. Drive from Charleston to St. Louiscar car 841 mi
    14h 43m
    $154–222

  5. Fly from Greenville–Spartanburg International Airport

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL)plane plane GSP - STL
    4h 16m
    $164–751

  6. Drive, bus, taxi, train

    1. Drive from Charleston to Sonic at Walmartcar car
    2. Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus bus 302
    3. Take the taxi from Bluffton Transfer Center to Savannah Stationtaxi taxi
    4. Take the train from Savannah Station to Jacksonvilletrain train
    5. Take the bus from Jacksonville to Atlanta Bus Stationbus bus
    6. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    27h 31m

South Carolina to St. Louis by bus

Calendar7Weekly Buses
Duration26h 43mAverage Duration
Ticket$159Cheapest Price
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Questions & Answers

Map of how to get from South Carolina to St. Louis.ExpandLaunch map view
  • Distance: 614.9 mi
  • Duration: 3h 14m

What companies run services between South Carolina, USA and St. Louis, MO, USA?

You can take a bus from Mary St / Meeting St to St Louis Bus Station via N. Charleston SuperStop, North Charleston Transit Center, Charleston Bus Station, and Atlanta Bus Station in around 26h 43m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) hourly.

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