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How to get fromSouth Dakota to Mayo Clinicby plane, bus, or car

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There are 9 ways to get from South Dakota to Mayo Clinic by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Aberdeen Regional Airport to Minneapolis–Saint Paul International Airport, bus

    best
    1. Fly from Aberdeen Regional Airport (ABR) to Minneapolis–Saint Paul International Airport (MSP)plane plane ABR - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    4h 12m
    $119–427

  2. Drive 234.4 mi

    cheapest
    1. Drive from Sioux Falls to Mayo Cliniccar car 234.4 mi
    3h 51m
    $43–62

  3. Bus

    1. Take the bus from Sioux Falls to Minneapolisbus bus Jefferson Lines 702 / ...
    2. Take the bus from Minneapolis to Rochesterbus bus Jefferson Lines 965
    10h 39m
    $98–144

  4. Fly Watertown Municipal Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Watertown Municipal Airport (ATY) to Minneapolis–Saint Paul International Airport (MSP)plane plane ATY - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    4h 11m
    $112–414

  5. Fly Sioux Falls to Rochester

    1. Fly from Sioux Falls (FSD) to Rochester (RST)plane plane FSD - RST
    8h 15m
    $50–344

  6. Fly Rapid City to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Rapid City (RAP) to Minneapolis–Saint Paul International Airport (MSP)plane plane RAP - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 52m
    $138–487

  7. Fly Sioux Falls to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Sioux Falls (FSD) to Minneapolis–Saint Paul International Airport (MSP)plane plane FSD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 20m
    $106–406

  8. Bus via Fairmont

    1. Take the bus from Sioux Falls to Fairmontbus bus
    2. Take the bus from Fairmont to Minneapolisbus bus
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    11h 38m
    $130–176

  9. Bus via Minneapolis Airport (MSP)

    1. Take the bus from Sioux Falls to Minneapolis-St. Paulbus bus Jefferson Lines 926
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus Groome Transportation
    12h 53m
    $128–164

Aberdeen Regional Airport (ABR) to Minneapolis–Saint Paul International Airport (MSP) flights

Calendar14Weekly Planes
Duration1h 12mAverage Duration
Ticket$55Cheapest Price
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Questions & Answers

Map of how to get from South Dakota to Mayo Clinic.ExpandLaunch map view
  • Distance: 340.8 mi
  • Duration: 4h 12m

What companies run services between South Dakota, USA and Mayo Clinic, MN, USA?

You can take a bus from 6th/St. Paul NE corner to Mayo Clinic via The Bus Stop, Maple/Career NE corner, Sioux Falls, Minneapolis, and Rochester in around 10h 39m. Alternatively, Delta, American Airlines, and United Airlines fly from Sioux Falls (FSD) to Rochester (RST) 5 times a day.

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