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How to get fromSouthampton to St. Louisby bus, plane, or train

Find Transport to St. Louis

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There are 5 ways to get from Southampton to St. Louis by bus, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to London Heathrow Airport, fly to Lambert–St. Louis International Airport

    best
    1. Take the bus from Coach Station to Heathrow Terminal 5bus bus
    2. Fly from London Heathrow Airport (LHR) to Lambert–St. Louis International Airport (STL)plane plane LHR - STL
    13h 29m
    $518–2,026

  2. Bus to London Heathrow Airport, fly to Decatur Airport, bus

    cheapest
    1. Take the bus from Coach Station to Heathrow Terminal 5bus bus
    2. Fly from London Heathrow Airport (LHR) to Decatur Airport (DEC)plane plane LHR - DEC
    3. Take the bus from Decatur Downtown Transportation Center to St Louis Bus Stationbus bus
    18h 57m
    $339–1,175

  3. Bus to London Heathrow Airport, fly to Abraham Lincoln Capital Airport, train

    1. Take the bus from Coach Station to Heathrow Terminal 5bus bus
    2. Fly from London Heathrow Airport (LHR) to Abraham Lincoln Capital Airport (SPI)plane plane LHR - SPI
    3. Take the train from Springfield to St. Louistrain train
    17h 21m
    $344–1,209

  4. Bus to London Heathrow Airport, fly to Williamson County Regional Airport, bus

    1. Take the bus from Coach Station to Heathrow Terminal 5bus bus
    2. Fly from London Heathrow Airport (LHR) to Williamson County Regional Airport (MWA)plane plane LHR - MWA
    3. Take the bus from Carbondale to St. Louisbus bus
    22h 1m
    $379–1,398

  5. Fly Southampton Airport to Lambert–St. Louis International Airport

    1. Fly from Southampton Airport (SOU) to Lambert–St. Louis International Airport (STL)plane plane SOU - STL
    16h 41m
    $475–1,807

London Heathrow Airport (LHR) to Lambert–St. Louis International Airport (STL) flights

Calendar57Weekly Planes
Duration11h 59mAverage Duration
Ticket$394Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Southampton to St. Louis.ExpandLaunch map view
  • Distance: 4,269.2 mi
  • Duration: 13h 29m

What companies run services between Southampton, England and St. Louis, MO, USA?

KLM, American Airlines, and three other airlines fly from Southampton Airport (SOU) to Lambert–St. Louis International Airport (STL) 5 times a day.

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Bus operators

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