Rome2Rio

How to get fromSouthampton to St. Louisby train, plane, or bus

Find Transport to St. Louis

See all options

There are 6 ways to get from Southampton to St. Louis by train, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, train to London Heathrow Airport, fly to Lambert–St. Louis International Airport

    best
    1. Take the train from Southampton Central to Readingtrain train
    2. Take the train from Reading to Hayes And Harlington Stationtrain train
    3. Fly from London Heathrow Airport (LHR) to Lambert–St. Louis International Airport (STL)plane plane LHR - STL
    13h 47m
    $466–1,601

  2. Train, train to London Heathrow Airport, fly to Williamson County Regional Airport, bus

    cheapest
    1. Take the train from Southampton Central to Readingtrain train
    2. Take the train from Reading to Hayes And Harlington Stationtrain train
    3. Fly from London Heathrow Airport (LHR) to Williamson County Regional Airport (MWA)plane plane LHR - MWA
    4. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    21h 8m
    $378–1,161

  3. Train, train to London Gatwick Airport, fly to Lambert–St. Louis International Airport

    1. Take the train from Southampton Central to Barnhamtrain train
    2. Take the train from Barnham to Gatwick Airporttrain train
    3. Fly from London Gatwick Airport (LGW) to Lambert–St. Louis International Airport (STL)plane plane LGW - STL
    17h 47m
    $459–1,382

  4. Train, train to London Heathrow Airport, fly to Abraham Lincoln Capital Airport

    1. Take the train from Southampton Central to Readingtrain train
    2. Take the train from Reading to Hayes And Harlington Stationtrain train
    3. Fly from London Heathrow Airport (LHR) to Abraham Lincoln Capital Airport (SPI)plane plane LHR - SPI
    4. Take the train from Springfield to St. Louistrain train
    19h 52m
    $406–1,299

  5. Fly Southampton Airport to Lambert–St. Louis International Airport

    1. Fly from Southampton Airport (SOU) to Lambert–St. Louis International Airport (STL)plane plane SOU - STL
    16h 11m
    $505–1,907

  6. Train, train to London Heathrow Airport, fly to Decatur Airport, bus

    1. Take the train from Southampton Central to Readingtrain train
    2. Take the train from Reading to Hayes And Harlington Stationtrain train
    3. Fly from London Heathrow Airport (LHR) to Decatur Airport (DEC)plane plane LHR - DEC
    4. Take the bus from Decatur Downtown Transportation Center to St Louis Bus Stationbus bus
    18h 52m
    $379–1,250

London Heathrow Airport (LHR) to Lambert–St. Louis International Airport (STL) flights

Calendar52Weekly Planes
Duration11h 43mAverage Duration
Ticket$399Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Southampton to St. Louis.ExpandLaunch map view
  • Distance: 4,279.1 mi
  • Duration: 13h 47m

What companies run services between Southampton, England and St. Louis, MO, USA?

KLM, American Airlines, and Air Canada fly from Southampton Airport (SOU) to Lambert–St. Louis International Airport (STL) 4 times a week.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides