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How to get fromSouthaven to St. Louisby bus (Flixbus, Greyhound), car, or plane

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There are 3 ways to get from Southaven to St. Louis by bus (Flixbus, Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Memphis Bus Station to St Louis Bus Stationbus bus FlixBus 2510
    6h 1m
    $46–91

  2. Drive 295.3 mi

    1. Drive from Southaven to St. Louiscar car 295.3 mi
    4h 47m
    $54–78

  3. Fly

    1. Fly from Memphis (MEM) to Lambert–St. Louis International Airport (STL)plane plane MEM - STL
    5h 14m
    $114–654

Southaven to St. Louis by bus

Calendar14Weekly Buses
Duration6h 1mAverage Duration
Ticket$46Cheapest Price
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Questions & Answers

Map of how to get from Southaven to St. Louis.ExpandLaunch map view
  • Distance: 294.9 mi
  • Duration: 6h 1m

What companies run services between Southaven, MS, USA and St. Louis, MO, USA?

Flixbus USA operates a bus from Memphis Bus Station to St Louis Bus Station once daily. Tickets cost $45–80 and the journey takes 4h 45m. Greyhound USA also services this route once daily. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Memphis (MEM) to Lambert–St. Louis International Airport (STL) hourly.

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