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How to get fromSpartanburg to Buffaloby plane, bus (Greyhound), train (Amtrak), car, train, or bus

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There are 6 ways to get from Spartanburg to Buffalo by plane, bus (Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF)plane plane GSP - BUF
    5h 7m
    $167–719

  2. Bus

    cheapest
    1. Take the bus from Spartanburg to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Charleston, WVbus bus
    3. Take the bus from Charleston, WV to Cleveland, OHbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    19h 20m
    $112–238

  3. Train (Amtrak)

    1. Take the train from Spartanburg Station to Ny Moynihan Train Hall At Penn Stationtrain train Crescent
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    25h 13m
    $289–650

  4. Drive  708 mi

    1. Drive from Spartanburg to Buffalocar car 708 mi
    12h 37m
    $130–187

  5. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Buffalo Niagara International Airport (BUF)plane plane CLT - BUF
    7h 13m
    $127–653

  6. Train, bus

    1. Take the train from Spartanburg Station to High Pointtrain train
    2. Take the bus from High Point to Winston-Salembus bus
    3. Take the bus from Winston Salem to Charlestonbus bus
    4. Take the bus from Charleston to Akronbus bus
    5. Take the bus from Akron to Buffalobus bus
    22h 17m
    $113–288

Spartanburg to Buffalo by train (Amtrak)

Calendar7Weekly Trains
Duration25h 13mAverage Duration
Ticket$289Cheapest Price
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Questions & Answers

Map of how to get from Spartanburg to Buffalo.ExpandLaunch map view
  • Distance: 615.3 mi
  • Duration: 5h 7m

What companies run services between Spartanburg, SC, USA and Buffalo, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a vehicle from Spartanburg to Buffalo, NY via Spartanburg, Charlotte Bus Station, Charleston, WV, and Cleveland, OH in around 19h 20m.

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