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How to get fromSpartanburg to Buffaloby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

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There are 6 ways to get from Spartanburg to Buffalo by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF)plane plane GSP - BUF
    5h 22m
    $161–744

  2. Train, bus

    cheapest
    1. Take the train from Spartanburg Station to High Pointtrain train
    2. Take the bus from Winston Salem(Trans Center) to Charleston, WVbus bus
    3. Take the bus from Charleston to Akronbus bus
    4. Take the bus from Akron to Buffalobus bus
    22h 5m
    $105–287

  3. Bus

    1. Take the bus from Spartanburg to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Columbus - Mound Stbus bus
    3. Take the bus from Columbus to Buffalobus bus
    21h
    $150–231

  4. Train (Amtrak)

    1. Take the train from Spartanburg Station to Ny Moynihan Train Hall At Penn Stationtrain train Crescent
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    25h 13m
    $268–675

  5. Drive  708 mi

    1. Drive from Spartanburg to Buffalocar car 708 mi
    12h 37m
    $130–187

  6. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Buffalo Niagara International Airport (BUF)plane plane CLT - BUF
    7h 5m
    $125–680

Spartanburg to Buffalo by train (Amtrak)

Calendar7Weekly Trains
Duration25h 13mAverage Duration
Ticket$268Cheapest Price
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Comparing Your Travel Options

Map of how to get from Spartanburg to Buffalo.ExpandLaunch map view
  • Distance: 615.2 mi
  • Duration: 5h 22m

What companies run services between Spartanburg, SC, USA and Buffalo, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a vehicle from Spartanburg to Buffalo via Spartanburg, Charlotte Bus Station, Columbus - Mound St, S Grant Ave & E Mound St, S High St & E Rich St, and Columbus in around 21h.

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