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How to get fromSpartanburg to Chicagoby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

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There are 8 ways to get from Spartanburg to Chicago by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD)plane plane GSP - ORD
    3h 22m
    $123–441

  2. Drive to Asheville Regional Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Drive from Spartanburg to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Chicago O'Hare International Airport (ORD)plane plane AVL - ORD
    3h 51m
    $62–309

  3. Bus

    1. Take the bus from Spartanburg to Atlanta Bus Stationbus bus Greyhound US0670
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    21h 13m
    $152–294

  4. Train (Amtrak)

    1. Take the train from Spartanburg Station to Charlottesvilletrain train Crescent
    2. Take the train from Charlottesville to Chicago Union Stationtrain train Cardinal
    29h 43m
    $371–772

  5. Drive 673.4 mi

    1. Drive from Spartanburg to Chicagocar car 673.4 mi
    12h 45m
    $123–178

  6. Drive to Asheville Regional Airport, fly to Chicago Midway International Airport

    1. Drive from Spartanburg to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Chicago Midway International Airport (MDW)plane plane AVL - MDW
    6h 7m
    $82–379

  7. Train, bus

    1. Take the train from Spartanburg Station to High Pointtrain train
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus - Mound St to Chicagobus bus
    24h 40m
    $117–275

  8. Train via Cary (Amtrak)

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Take the train from Charlotte Amtrak Station to Carytrain train
    3. Take the train from Cary to Chicago Union Stationtrain train
    32h 15m
    $425–910

Spartanburg to Chicago by train (Amtrak)

Calendar3Weekly Trains
Duration29h 43mAverage Duration
Ticket$371Cheapest Price
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Questions & Answers

Map of how to get from Spartanburg to Chicago.ExpandLaunch map view
  • Distance: 615 mi
  • Duration: 3h 22m

What companies run services between Spartanburg, SC, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, you can take a vehicle from Spartanburg to Chicago Bus Station via Spartanburg and Atlanta Bus Station in around 21h 13m.

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