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How to get fromSpartanburg to Des Moinesby plane, bus (Greyhound, Flixbus), car, or bus

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There are 5 ways to get from Spartanburg to Des Moines by plane, bus (Greyhound, Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Des Moines (DSM)plane plane GSP - DSM
    5h 3m
    $253–987

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Spartanburg to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Des Moines (DSM)plane plane AVL - DSM
    5h 34m
    $167–735

  3. Bus

    1. Take the bus from Spartanburg to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    24h 50m

  4. Drive 960.4 mi

    1. Drive from Spartanburg to Des Moinescar car 960.4 mi
    17h 29m
    $176–254

  5. Bus to Charlotte Douglas International Airport, fly

    1. Take the bus from Spartanburg to Charlottebus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    6h 12m

Greenville–Spartanburg International Airport (GSP) to Des Moines (DSM) flights

Calendar90Weekly Planes
Duration5h 57mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from Spartanburg to Des Moines.ExpandLaunch map view
  • Distance: 796.4 mi
  • Duration: 5h 3m

What companies run services between Spartanburg, SC, USA and Des Moines, IA, USA?

United Airlines, American Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Spartanburg to Des Moines via Atlanta Bus Station and St Louis Bus Station in around 24h 50m.

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