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How to get fromSpartanburg to Des Moinesby plane, bus (Greyhound, Flixbus), train, bus, or car

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There are 8 ways to get from Spartanburg to Des Moines by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Des Moines (DSM)plane plane GSP - DSM
    5h 9m
    $149–499

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Spartanburg to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Des Moines (DSM)plane plane AVL - DSM
    5h 48m
    $107–456

  3. Bus

    1. Take the bus from Spartanburg to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    27h 45m
    $218–351

  4. Train, bus via Charlottesville

    1. Take the train from Spartanburg Station to Charlottesvilletrain train
    2. Take the train from Charlottesville to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    35h 3m
    $598–969

  5. Drive  960.4 mi

    1. Drive from Spartanburg to Des Moinescar car 960.4 mi
    17h 30m
    $165–238

  6. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    6h 46m
    $151–554

  7. Train, bus

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Take the bus from Charlotte to Columbusbus bus
    3. Take the bus from Columbus to Chicagobus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    30h 23m
    $181–346

  8. Train, bus via Chicago

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Take the train from Charlotte Amtrak Station to Carytrain train
    3. Take the train from Cary to Chicago Union Stationtrain train
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    39h 54m
    $742–1,250

Spartanburg to Des Moines by train and bus

Calendar3Weekly Services
Duration35h 3mAverage Duration
Ticket$598Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Spartanburg to Des Moines.ExpandLaunch map view
  • Distance: 796.4 mi
  • Duration: 5h 9m

What companies run services between Spartanburg, SC, USA and Des Moines, IA, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Des Moines (DSM) hourly. Alternatively, you can take a vehicle from Spartanburg to Des Moines via Spartanburg, Atlanta Bus Station, and Indianapolis Union Station in around 27h 45m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

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