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How to get fromSpartanburg to Florida Keysby plane, bus (Greyhound, Flixbus), bus, train, shuttle, or car

Find Transport to Florida Keys

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There are 9 ways to get from Spartanburg to Florida Keys by plane, bus (Greyhound, Flixbus), bus, train, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Key West International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    7h 8m
    $203–530

  2. Drive to Asheville Regional Airport, fly to Key West International Airport

    cheapest
    1. Drive from Spartanburg to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    5h 54m
    $147–438

  3. Bus

    1. Take the bus from Spartanburg to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 50m
    $160–270

  4. Bus, train, shuttle

    1. Take the bus from Spartanburg to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Miami Amtrak Stationtrain train
    3. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    25h 55m
    $389–664

  5. Drive  864.2 mi

    1. Drive from Spartanburg to Florida Keyscar car 864.2 mi
    14h 54m
    $158–228

  6. Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane plane GSP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 54m
    $288–710

  7. Fly Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane GSP - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 26m
    $358–760

  8. Train to Charlotte Douglas International Airport, fly to Key West International Airport

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane plane CLT - EYW
    9h 21m
    $168–494

  9. Train, bus

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Take the train from Charlotte Amtrak Station to Carytrain train
    3. Take the train from Cary to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    35h 14m
    $350–802

Spartanburg to Florida Keys by train, taxi, bus, and foot

Calendar7Weekly Services
Duration35h 14mAverage Duration
Ticket$350Cheapest Price
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Comparing Your Travel Options

Map of how to get from Spartanburg to Florida Keys.ExpandLaunch map view
  • Distance: 755.1 mi
  • Duration: 7h 8m

What companies run services between Spartanburg, SC, USA and Florida Keys, FL, USA?

American Airlines, Allegiant Air, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Spartanburg to Florida Keys via Spartanburg, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 24h 50m.

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