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How to get fromSpartanburg to Florida Keysby plane, bus (Flixbus, Greyhound), train, bus, car, shuttle, or bus (Greyhound)

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There are 9 ways to get from Spartanburg to Florida Keys by plane, bus (Flixbus, Greyhound), train, bus, car, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Key West International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    7h 14m
    $213–560

  2. Drive to Asheville Regional Airport, fly to Key West International Airport

    cheapest
    1. Drive from Spartanburg to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    5h 58m
    $152–438

  3. Bus

    1. Take the bus from Spartanburg to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 55m
    $187–337

  4. Train, bus

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Take the train from Charlotte Amtrak Station to Carytrain train
    3. Take the train from Cary to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    35h 14m
    $441–893

  5. Drive 864.2 mi

    1. Drive from Spartanburg to Florida Keyscar car 864.2 mi
    14h 54m
    $158–228

  6. Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane plane GSP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 55m
    $293–700

  7. Fly Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane GSP - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 22m
    $368–1,070

  8. Bus to Charlotte Douglas International Airport, fly to Key West International Airport

    1. Take the bus from Spartanburg to Charlottebus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane plane CLT - EYW
    8h 42m
    $192–550

  9. Bus via Pembroke Pines

    1. Take the bus from Spartanburg to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Hollywood Sheridan Trirail Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    28h 46m
    $240–343

Spartanburg to Florida Keys by bus and foot

Calendar14Weekly Services
Duration24h 55mAverage Duration
Ticket$187Cheapest Price
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Questions & Answers

Map of how to get from Spartanburg to Florida Keys.ExpandLaunch map view
  • Distance: 755.1 mi
  • Duration: 7h 14m

What companies run services between Spartanburg, SC, USA and Florida Keys, FL, USA?

Delta, American Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Spartanburg to Florida Keys via Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 24h 55m.

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