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How to get fromSpartanburg to Indianapolisby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Flixbus)

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There are 6 ways to get from Spartanburg to Indianapolis by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Indianapolis (IND)plane plane GSP - IND
    5h 2m
    $143–618

  2. Drive  493.9 mi

    cheapest
    1. Drive from Spartanburg to Indianapoliscar car 493.9 mi
    9h 34m
    $85–122

  3. Bus

    1. Take the bus from Spartanburg to Atlanta Bus Stationbus bus Greyhound US0670
    2. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus Greyhound US0100
    16h 55m
    $143–221

  4. Train (Amtrak)

    1. Take the train from Spartanburg Station to Charlottesvilletrain train Crescent
    2. Take the train from Charlottesville to Indianapolistrain train Cardinal
    24h 13m
    $518–839

  5. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Indianapolis (IND)plane plane CLT - IND
    6h 50m
    $135–623

  6. Bus via Sandy Springs

    1. Take the bus from Servicios Zapata - Spartanburg to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Indianapolisbus bus FlixBus 2512
    17h 38m
    $139–216

Spartanburg to Indianapolis by train (Amtrak)

Calendar3Weekly Trains
Duration24h 13mAverage Duration
Ticket$518Cheapest Price
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Comparing Your Travel Options

Map of how to get from Spartanburg to Indianapolis.ExpandLaunch map view
  • Distance: 434.4 mi
  • Duration: 5h 2m

What companies run services between Spartanburg, SC, USA and Indianapolis, IN, USA?

Delta, Southwest Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Indianapolis (IND) hourly. Alternatively, you can take a vehicle from Spartanburg to Indianapolis Union Station via Spartanburg and Atlanta Bus Station in around 16h 55m.

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Need to know: Greyhound

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