There are 7 ways to get from Spartanburg to Key West by plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Greenville–Spartanburg International Airport
best- Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane GSP - EYW
4h 22m$137–449Drive to Asheville Regional Airport, fly
cheapest- Drive from Spartanburg to Asheville-Airport-AVLcar
- Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane AVL - EYW
3h 8m$81–357Bus
- Take the bus from Spartanburg to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
25h 37m$160–270Bus, train
- Take the bus from Spartanburg to Charleston Bus Stationbus
- Take the train from Charleston Amtrak Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
27h 8m$253–514Drive 879.7 mi
- Drive from Spartanburg to Key Westcar 879.7 mi
15h 17m$161–232Bus, shuttle
- Take the bus from Servicios Zapata - Spartanburg to Atlantabus
- Take the bus from Atlanta Bus Station to Miami Airport Stationbus
- Take a shuttle bus from Miami, FL - International Airport to Key West, FL
25h 39m$321–450Train, bus
- Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain
- Take the train from Charlotte Amtrak Station to Carytrain
- Take the train from Cary to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
36h 1m$350–802
Spartanburg to Key West by train, taxi, bus, and foot
Comparing Your Travel Options
The cheapest way to get from Spartanburg to Key West is to drive which costs $160 - $240 and takes 15h 17m.
The fastest way to get from Spartanburg to Key West is to drive and fly which takes 3h 8m and costs $80 - $360.
No, there is no direct bus from Spartanburg to Key West. However, there are services departing from Spartanburg and arriving at N Roosevelt & 3rd Street via Atlanta Bus Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 25h 37m.
The distance between Spartanburg and Key West is 740 miles. The road distance is 884.8 miles.
The best way to get from Spartanburg to Key West without a car is to bus which takes 25h 37m and costs $160 - $270.
It takes approximately 4h 22m to get from Spartanburg to Key West, including transfers.
Spartanburg to Key West bus services, operated by Greyhound USA, depart from Spartanburg station.
The best way to get from Spartanburg to Key West is to fly which takes 4h 22m and costs $130 - $450. Alternatively, you can bus, which costs $160 - $270 and takes 25h 37m.
Spartanburg to Key West bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Yes, the driving distance between Spartanburg to Key West is 885 miles. It takes approximately 15h 17m to drive from Spartanburg to Key West.
What companies run services between Spartanburg, SC, USA and Key West, FL, USA?
American Airlines, Allegiant Air, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Spartanburg to N Roosevelt & 3rd Street via Spartanburg, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 25h 37m.
- Website
- aa.com
Flights from Greenville–Spartanburg International Airport to Key West International Airport via Miami
- Ave. Duration
- 4h 25m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $70–380
Flights from Greenville–Spartanburg International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 4h 58m
- When
- Every day
- Estimated price
- $75–390
Flights from Asheville Regional Airport to Key West International Airport via Miami
- Ave. Duration
- 3h 58m
- When
- Every day
- Estimated price
- $65–340
Flights from Asheville Regional Airport to Key West International Airport via Charlotte
- Ave. Duration
- 5h 2m
- When
- Every day
- Estimated price
- $65–340
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Charleston Amtrak Station to Miami Amtrak Station
- Ave. Duration
- 14h 3m
- Frequency
- Once daily
- Estimated price
- $170–380
- Website
- Amtrak
Train from Spartanburg Station to Charlotte Amtrak Station
- Ave. Duration
- 2h 2m
- Frequency
- Once daily
- Estimated price
- $19–45
- Website
- Amtrak
Train from Charlotte Amtrak Station to Cary
- Ave. Duration
- 3h 1m
- Frequency
- 5 times a day
- Estimated price
- $40–95
- Website
- Amtrak
Train from Cary to Miami Amtrak Station
- Ave. Duration
- 21h 53m
- Frequency
- Once daily
- Estimated price
- $250–600
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Spartanburg to Atlanta Bus Station
- Ave. Duration
- 4h
- Frequency
- Twice daily
- Estimated price
- $27–45
- Website
- Greyhound
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 17h 20m
- Frequency
- Once daily
- Estimated price
- $100–170
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–35
- Website
- Greyhound
Bus from Spartanburg to Charleston Bus Station
- Ave. Duration
- 4h 50m
- Frequency
- Once daily
- Estimated price
- $30–55
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–35
- Website
- Greyhound
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 17h 20m
- Frequency
- Once daily
- Estimated price
- $100–170
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–35
- Website
- Greyhound
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Booking & Getting There
There are 970+ hotels available in Key West.





