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How to get fromSpartanburg to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), car, train, or bus

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There are 6 ways to get from Spartanburg to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF)plane plane GSP - SDF
    4h 44m
    $152–669

  2. Drive 381.1 mi

    cheapest
    1. Drive from Spartanburg to Louisvillecar car 381.1 mi
    8h 3m
    $70–101

  3. Bus

    1. Take the bus from Spartanburg to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    14h 8m
    $106–194

  4. Drive to Asheville Regional Airport, fly

    1. Drive from Spartanburg to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Louisville International Airport (SDF)plane plane AVL - SDF
    5h 34m
    $91–497

  5. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    6h 48m
    $122–659

  6. Train, bus

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Take the bus from Charlotte Bus Station to Hurricanebus bus
    3. Take the bus from Hurricane to Columbus - Mound Stbus bus
    4. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus
    20h 38m
    $95–246

Spartanburg to Louisville by train, foot, tram, and bus

Calendar7Weekly Services
Duration20h 38mAverage Duration
Ticket$95Cheapest Price
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Questions & Answers

Map of how to get from Spartanburg to Louisville.ExpandLaunch map view
  • Distance: 325.4 mi
  • Duration: 4h 44m

What companies run services between Spartanburg, SC, USA and Louisville, KY, USA?

Southwest Airlines, Delta, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) hourly. Alternatively, you can take a vehicle from Spartanburg to Louisville, KY via Spartanburg, Atlanta Bus Station, and Nashville in around 14h 8m.

Airlines
Train operators
Bus operators

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