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How to get fromSpartanburg to St. Louisby plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

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There are 7 ways to get from Spartanburg to St. Louis by plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL)plane plane GSP - STL
    4h 25m
    $169–719

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Spartanburg to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Lambert–St. Louis International Airport (STL)plane plane AVL - STL
    5h 22m
    $113–567

  3. Bus

    1. Take the bus from Spartanburg to Atlantabus bus Acb 1152
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    15h 20m

  4. Train (Amtrak)

    1. Take the train from Spartanburg Station to Charlottesvilletrain train
    2. Take the train from Charlottesville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    35h 29m
    $461–962

  5. Drive 652.6 mi

    1. Drive from Spartanburg to St. Louiscar car 652.6 mi
    11h 5m
    $120–172

  6. Bus to Charlotte Douglas International Airport, fly

    1. Take the bus from Spartanburg to Charlottebus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    6h 17m

  7. Bus via Evansville

    1. Take the bus from Spartanburg to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    17h 5m

Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) flights

Calendar122Weekly Planes
Duration5hAverage Duration
Ticket$118Cheapest Price
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Questions & Answers

Map of how to get from Spartanburg to St. Louis.ExpandLaunch map view
  • Distance: 556.2 mi
  • Duration: 4h 25m

What companies run services between Spartanburg, SC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Spartanburg to St Louis Bus Station via Atlanta Bus Station in around 15h 20m.

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