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How to get fromSpartanburg to St. Louisby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Flixbus, Amtrak)

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There are 7 ways to get from Spartanburg to St. Louis by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL)plane plane GSP - STL
    4h 50m
    $154–669

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Spartanburg to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Lambert–St. Louis International Airport (STL)plane plane AVL - STL
    5h 46m
    $108–567

  3. Bus

    1. Take the bus from Spartanburg to Atlanta Bus Stationbus bus Greyhound US0670
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    16h 45m
    $120–206

  4. Train (Amtrak)

    1. Take the train from Spartanburg Station to Charlottesvilletrain train
    2. Take the train from Charlottesville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    35h 29m
    $339–838

  5. Drive  652.5 mi

    1. Drive from Spartanburg to St. Louiscar car 652.5 mi
    11h 5m
    $120–172

  6. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Spartanburg Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    6h 44m
    $123–604

  7. Bus via Carbondale

    1. Take the bus from Servicios Zapata - Spartanburg to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    17h 19m
    $128–211

Spartanburg to St. Louis by train (Amtrak)

Calendar3Weekly Trains
Duration35h 29mAverage Duration
Ticket$339Cheapest Price
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Comparing Your Travel Options

Map of how to get from Spartanburg to St. Louis.ExpandLaunch map view
  • Distance: 556.2 mi
  • Duration: 4h 50m

What companies run services between Spartanburg, SC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Spartanburg to St Louis Bus Station via Spartanburg and Atlanta Bus Station in around 16h 45m.

Airlines
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Need to know: Greyhound

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