There are 4 ways to get from Spoleto to Isernia by train (Trenitalia), bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Trenitalia)
best- Take the train from Spoleto to Roma Tiburtinatrain 4153 / ...
- Take the train from Roma Tiburtina to Iserniatrain Re
4h 37m€35–53Bus
cheapest- Take the bus from Palombara to Roma, Autostazione Tiburtinabus E433
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
6h 35m€23–44Drive 243.1 km
- Drive from Spoleto to Iserniacar 243.1 km
3h 36m€40–57Train via Rome (Trenitalia)
- Take the train from Spoleto to Roma Terminitrain 4153 / ...
- Take the train from Roma Termini to Iserniatrain Re
4h 49m€36–64
Spoleto to Isernia by train (Trenitalia)
Comparing Your Travel Options
The cheapest way to get from Spoleto to Isernia is to bus which costs €23 - €45 and takes 6h 35m.
The fastest way to get from Spoleto to Isernia is to drive which takes 3h 36m and costs €35 - €60.
No, there is no direct bus from Spoleto to Isernia. However, there are services departing from Via Nursina and arriving at Isernia via Palombara and Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 35m.
No, there is no direct train from Spoleto to Isernia. However, there are services departing from Spoleto and arriving at Isernia via Roma Tiburtina. The journey, including transfers, takes approximately 4h 37m.
The distance between Spoleto and Isernia is 305 km. The road distance is 243.1 km.
The best way to get from Spoleto to Isernia without a car is to train which takes 4h 37m and costs €35 - €55.
It takes approximately 4h 37m to get from Spoleto to Isernia, including transfers.
Spoleto to Isernia bus services, operated by Busitalia Umbria, depart from Palombara station.
Spoleto to Isernia train services, operated by Trenitalia, depart from Spoleto station.
The best way to get from Spoleto to Isernia is to train which takes 4h 37m and costs €35 - €55. Alternatively, you can bus, which costs €23 - €45 and takes 6h 35m.
What companies run services between Spoleto, Italy and Isernia, Italy?
You can take a train from Spoleto to Isernia via Roma Tiburtina in around 4h 37m. Alternatively, you can take a bus from Via Nursina to Isernia via Palombara and Roma, Autostazione Tiburtina in around 6h 35m.
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Spoleto to Roma Tiburtina
- Ave. Duration
- 1h 23m
- Frequency
- Every 2 hours
- Estimated price
- €14–20
- Website
- Trenitalia
Train from Roma Tiburtina to Isernia
- Ave. Duration
- 2h 14m
- Frequency
- 6 times a week
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Spoleto to Roma Termini
- Ave. Duration
- 1h 41m
- Frequency
- Every 2 hours
- Estimated price
- €14–21
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–35
- Website
- Trenitalia
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Spoleto to Roma Tiburtina
- Ave. Duration
- 1h 25m
- Frequency
- 3 times a day
- Estimated price
- €13–24
- Website
- Trenitalia Intercity
Train from Spoleto to Roma Termini
- Ave. Duration
- 1h 44m
- Frequency
- 3 times a day
- Estimated price
- €13–25
- Website
- Trenitalia Intercity
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Spoleto to Roma Termini
- Ave. Duration
- 1h 22m
- Frequency
- Once daily
- Estimated price
- €17–29
- Website
- Trenitalia Frecce
- Phone
- +39 06 44101
- [email protected]
- Website
- fsbusitalia.it
Bus from Palombara to Roma, Autostazione Tiburtina
- Ave. Duration
- 2h 17m
- Frequency
- Once a week
- Estimated price
- €13–18
- Schedules at
- Busitalia Umbria
- Phone
- +39 0874 64744
- [email protected]
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- €15–23
- Website
- Flixbus
Want to know more about travelling around Italy
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Booking & Getting There
Spoleto to Isernia bus services, operated by Busitalia Umbria, arrive at Roma, Autostazione Tiburtina station.
Spoleto to Isernia train services, operated by Trenitalia, arrive at Roma Tiburtina station.
Yes, the driving distance between Spoleto to Isernia is 243 km. It takes approximately 3h 36m to drive from Spoleto to Isernia.
Book your Spoleto to Isernia train tickets online with Omio.
There are 459+ hotels available in Isernia.