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How to get fromSpringfield to Mayo Clinicby plane, train, bus, car, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Springfield to Mayo Clinic by plane, train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Abraham Lincoln Capital Airport to Rochester

    best
    1. Fly from Abraham Lincoln Capital Airport (SPI) to Rochester (RST)plane plane SPI - RST
    5h 21m
    $70–407

  2. Train, bus via Madison

    1. Take the train from Springfield to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h
    $124–237

  3. Train, bus

    1. Take the train from Springfield to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    14h 18m
    $177–387

  4. Drive  398.4 mi

    1. Drive from Springfield to Mayo Cliniccar car 398.4 mi
    7h 42m
    $73–105

  5. Bus to Peoria International Airport, fly to Rochester

    1. Take the bus from Springfield to Peoria Amtrak Stationbus bus
    2. Fly from Peoria International Airport (PIA) to Rochester (RST)plane plane PIA - RST
    8h 7m
    $76–409

  6. Train to Lambert–St. Louis International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Springfield to St. Louistrain train
    2. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 54m
    $460–1,061

  7. Bus

    1. Take the bus from Springfield SMTD Transfer Center to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    13h 38m
    $116–172

Springfield to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration13hAverage Duration
Ticket$124Cheapest Price
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Questions & Answers

Map of how to get from Springfield to Mayo Clinic.ExpandLaunch map view
  • Distance: 329.8 mi
  • Duration: 5h 21m

What companies run services between Springfield, IL, USA and Mayo Clinic, MN, USA?

American Airlines flies from Abraham Lincoln Capital Airport (SPI) to Rochester (RST) once daily. Alternatively, you can take a bus from Springfield SMTD Transfer Center to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 13h 38m.

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