What is the cheapest way to get from Springfield to Mayo Clinic?

The cheapest way to get from Springfield to Mayo Clinic is to drive which costs $70 - $110 and takes 7h 42m.

What is the fastest way to get from Springfield to Mayo Clinic?

The fastest way to get from Springfield to Mayo Clinic is to fly which takes 5h 13m and costs $80 - $370.

Is there a direct bus between Springfield and Mayo Clinic?

No, there is no direct bus from Springfield to Mayo Clinic. However, there are services departing from Springfield SMTD Transfer Center and arriving at Rochester via Chicago Bus Station and Milwaukee. The journey, including transfers, takes approximately 13h 40m.

How far is it from Springfield to Mayo Clinic?

The distance between Springfield and Mayo Clinic is 332 miles. The road distance is 400.7 miles.

How do I travel from Springfield to Mayo Clinic without a car?

The best way to get from Springfield to Mayo Clinic without a car is to train and bus via Madison which takes 12h 58m and costs $130 - $260.

How long does it take to get from Springfield to Mayo Clinic?

It takes approximately 5h 13m to get from Springfield to Mayo Clinic, including transfers.

Where do I catch the Springfield to Mayo Clinic bus from?

Springfield to Mayo Clinic bus services, operated by Jefferson Lines, depart from Springfield SMTD Transfer Center station.

Bus or fly from Springfield to Mayo Clinic?

The best way to get from Springfield to Mayo Clinic is to fly which takes 5h 13m and costs $80 - $370. Alternatively, you can bus via Milwaukee, which costs $120 - $190 and takes 13h 40m.

Where does the Springfield to Mayo Clinic bus arrive?

Springfield to Mayo Clinic bus services, operated by Jefferson Lines, arrive at Chicago Bus Station.

Can I drive from Springfield to Mayo Clinic?

Yes, the driving distance between Springfield to Mayo Clinic is 401 miles. It takes approximately 7h 42m to drive from Springfield to Mayo Clinic.

Where can I stay near Mayo Clinic?

There are 74+ hotels available in Mayo Clinic.

Springfield to Mayo Clinic - 7 ways to travel via train, plane, bus, and car

How to get fromSpringfield to Mayo Clinic

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There are 7 ways to get from Springfield to Mayo Clinic by plane, train, bus, car, bus (Flixbus, Greyhound), or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly from Abraham Lincoln Capital Airport
best
1. Fly from Abraham Lincoln Capital Airport (SPI) to Rochester (RST)plane SPI - RST
5h 13m
$83–368
Drive 398.4 mi
cheapest
1. Drive from Springfield to Mayo Cliniccar 398.4 mi
7h 42m
$73–105
Train, bus via Madison
1. Take the train from Springfield to Chicago Union Stationtrain
2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus
3. Take the bus from Madison to Rochesterbus
12h 58m
$135–251
Train, bus
1. Take the train from Springfield to Chicago Union Stationtrain
2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain
3. Take the bus from St. Paul to Rochester, MNbus
14h 23m
$218–431
Bus to Peoria International Airport, fly
1. Take the bus from Springfield to Peoria Amtrak Stationbus
2. Fly from Peoria International Airport (PIA) to Rochester (RST)plane PIA - RST
8h 17m
$94–376
Bus via Milwaukee
1. Take the bus from Springfield SMTD Transfer Center to Chicago Bus Stationbus
2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus
3. Take the bus from Milwaukee to Rochesterbus
13h 40m
$120–185
Bus
1. Take the bus from Springfield to Galesburg Amtrak Stationbus
2. Take the bus from Galesburg to Des Moinesbus
3. Take the bus from Des Moines to Albert Leabus
4. Take the bus from Albert Lea to Rochesterbus
14h 48m
$137–226

Springfield to Mayo Clinic by train, bus, and foot

21Weekly Services

14h 23mAverage Duration

$218Cheapest Price

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Questions & Answers

Map of how to get from Springfield to Mayo Clinic.

Launch map view

Distance: 329.8 mi
Duration: 5h 13m

What companies run services between Springfield, IL, USA and Mayo Clinic, MN, USA?

American Airlines flies from Abraham Lincoln Capital Airport (SPI) to Rochester (RST) twice daily. Alternatively, you can take a bus from Springfield SMTD Transfer Center to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 13h 40m.

Airlines

Train operators

Bus operators

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