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How to get fromSpringfield to Knoxvilleby plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Springfield to Knoxville by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Springfield-Branson National Airport (SGF) to Mcghee Tyson Airport (TYS)plane plane SGF - TYS
    4h 15m
    $261–1,189

  2. Drive  603.9 mi

    cheapest
    1. Drive from Springfield to Knoxvillecar car 603.9 mi
    10h 31m
    $104–150

  3. Bus

    1. Take the bus from Springfield CU Transit Center to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    43h 32m
    $415–604

  4. Bus, train

    1. Take the bus from Springfield CU Transit Center to St Louis Bus Stationbus bus
    2. Take the train from St. Louis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    44h 50m
    $875–1,404

  5. Fly to Asheville Regional Airport, drive

    1. Fly from Springfield-Branson National Airport (SGF) to Asheville Regional Airport (AVL)plane plane SGF - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 44m
    $106–449

  6. Bus, train via Ossining

    1. Take the bus from Springfield CU Transit Center to St Louis Bus Stationbus bus
    2. Take the train from St. Louis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    45h 28m
    $840–1,281

  7. Bus via Auburn Gresham

    1. Take the bus from Springfield CU Transit Center to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Chicagobus bus
    3. Take the bus from Chicago to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 1h
    $336–491

Springfield-Branson National Airport (SGF) to Mcghee Tyson Airport (TYS) flights

Calendar96Weekly Planes
Duration5h 27mAverage Duration
Ticket$197Cheapest Price
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Comparing Your Travel Options

Map of how to get from Springfield to Knoxville.ExpandLaunch map view
  • Distance: 551.6 mi
  • Duration: 4h 15m

What companies run services between Springfield, MO, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Springfield-Branson National Airport (SGF) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Springfield CU Transit Center to Knoxville via St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 43h 32m.

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