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How to get fromSpringfield to Murphysboroby bus (Greyhound, Amtrak, Flixbus), car, plane, or bus

Find Transport to Murphysboro

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There are 5 ways to get from Springfield to Murphysboro by bus (Greyhound, Amtrak, Flixbus), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Springfield CU Transit Center to St Louis Bus Stationbus bus Greyhound US1210
    2. Take the bus from St. Louis to Carbondalebus bus Amtrak Thruway Connecting Service
    7h 15m
    $71–141

  2. Drive 281.8 mi

    cheapest
    1. Drive from Springfield to Murphysborocar car 281.8 mi
    5h 18m
    $52–75

  3. Fly to Barkley Regional Airport, drive

    1. Fly from Springfield-Branson National Airport (SGF) to Barkley Regional Airport (PAH)plane plane SGF - PAH
    2. Drive from Barkley Regional Airport (PAH) to Murphysborocar car
    7h 22m
    $109–440

  4. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Springfield-Branson National Airport (SGF) to Lambert–St. Louis International Airport (STL)plane plane SGF - STL
    2. Take the bus from St. Louis to Carbondalebus bus
    8h 15m
    $163–645

  5. Fly to Williamson County Regional Airport

    1. Fly from Springfield-Branson National Airport (SGF) to Williamson County Regional Airport (MWA)plane plane SGF - MWA
    5h 50m
    $141–489

Springfield-Branson National Airport (SGF) to Barkley Regional Airport (PAH) flights

Calendar14Weekly Planes
Duration5h 47mAverage Duration
Ticket$81Cheapest Price
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Questions & Answers

Map of how to get from Springfield to Murphysboro.ExpandLaunch map view
  • Distance: 331.1 mi
  • Duration: 7h 15m

What companies run services between Springfield, MO, USA and Murphysboro, IL, USA?

You can take a bus from Springfield CU Transit Center to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 7h 15m. Alternatively, United Airlines, Corporate Flight Management Inc, and two other airlines fly from Springfield-Branson National Airport (SGF) to Williamson County Regional Airport (MWA) 4 times a day.

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