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How to get fromSpringfield to Murphysboroby bus (Greyhound, Amtrak, Flixbus), car, or plane

Find Transport to Murphysboro

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There are 4 ways to get from Springfield to Murphysboro by bus (Greyhound, Amtrak, Flixbus), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Springfield CU Transit Center to St Louis Bus Stationbus bus Greyhound US1210
    2. Take the bus from St. Louis to Carbondalebus bus Amtrak Thruway Connecting Service
    7h 20m
    $64–128

  2. Drive 281.8 mi

    cheapest
    1. Drive from Springfield to Murphysborocar car 281.8 mi
    5h 18m
    $52–75

  3. Fly to Williamson County Regional Airport

    1. Fly from Springfield-Branson National Airport (SGF) to Williamson County Regional Airport (MWA)plane plane SGF - MWA
    5h 55m
    $141–499

  4. Fly to Barkley Regional Airport, drive

    1. Fly from Springfield-Branson National Airport (SGF) to Barkley Regional Airport (PAH)plane plane SGF - PAH
    2. Drive from Barkley Regional Airport (PAH) to Murphysborocar car
    7h 48m
    $109–450

Springfield-Branson National Airport (SGF) to Williamson County Regional Airport (MWA) flights

Calendar35Weekly Planes
Duration8h 36mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Springfield to Murphysboro.ExpandLaunch map view
  • Distance: 331.1 mi
  • Duration: 7h 20m

What companies run services between Springfield, MO, USA and Murphysboro, IL, USA?

You can take a bus from Springfield CU Transit Center to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 7h 20m. Alternatively, American Airlines, United Airlines, and Delta fly from Springfield-Branson National Airport (SGF) to Williamson County Regional Airport (MWA) 5 times a day.

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