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How to get fromSt. Catharines to Chicagoby bus, plane, train (Amtrak), bus (Greyhound), car, train, shuttle, or bus (Flixbus)

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There are 10 ways to get from St. Catharines to Chicago by bus, plane, train (Amtrak), bus (Greyhound), car, train, shuttle, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from St. Catharines, ON to Toronto Airportbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    6h 10m
    $351–1,148

  2. Bus via Detroit

    cheapest
    1. Take the bus from St. Catharines, ON - Bus Terminal to Toronto Union Stationbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicagobus bus
    18h 2m
    $94–214

  3. Train

    1. Take the train from St. Catharines to Buffalotrain train VIA Rail
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    14h 1m
    $182–498

  4. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    15h 30m
    $95–196

  5. Drive 508.4 mi

    1. Drive from St. Catharines to Chicagocar car 508.4 mi
    8h 29m
    $117–169

  6. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from St. Catharines to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    6h 55m
    $125–617

  7. Bus to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St. Catharines, ON - Bus Terminal to Toronto Union Stationbus bus
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    6h 28m
    $179–1,359

  8. Line 12 bus, shuttle, bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from St. Catharines Fairview Mall to Niagara Falls Bus Terminalbus bus
    2. Take a shuttle bus from Whirlpool State Park, NY to Niagara Falls USA Official Visitor Centershuttle bus
    3. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    4. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    6h 39m
    $173–452

  9. Bus to Toronto Island Airport, fly to Chicago Midway International Airport

    1. Take the bus from St. Catharines, ON - Bus Terminal to Toronto Union Stationbus bus
    2. Fly from Toronto Island Airport (YTZ) to Chicago Midway International Airport (MDW)plane plane YTZ - MDW
    6h 19m
    $149–479

  10. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    7h 2m
    $163–322

St. Catharines to Chicago by train

Calendar7Weekly Trains
Duration14h 1mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from St. Catharines to Chicago.ExpandLaunch map view
  • Distance: 522 mi
  • Duration: 6h 10m

What companies run services between St. Catharines, ON, Canada and Chicago, IL, USA?

You can take a train from St. Catharines to Chicago Union Station via Buffalo Depew Station in around 14h 1m. Alternatively, you can take a bus from St. Catharines Fairview Mall to Chicago Bus Station via Niagara Falls, Buffalo, and Cleveland Bus Station in around 15h 30m.

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