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How to get fromSt. Catharines to Chicagoby bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus)

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There are 9 ways to get from St. Catharines to Chicago by bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Niagara Falls to Buffalobus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    6h 41m
    $181–356

  2. Bus via Detroit

    cheapest
    1. Take the bus from St. Catharines, ON - Bus Terminal to Toronto Union Stationbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicagobus bus
    18h 2m
    $84–189

  3. Train

    1. Take the train from St. Catharines to Buffalotrain train VIA Rail
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    14h 1m
    $152–457

  4. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    15h 30m
    $88–186

  5. Drive  508.4 mi

    1. Drive from St. Catharines to Chicagocar car 508.4 mi
    8h 29m
    $117–169

  6. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Falls to Buffalobus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    6h 58m
    $191–346

  7. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from St. Catharines to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    6h 55m
    $124–627

  8. Bus to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St. Catharines, ON - Bus Terminal to Toronto Union Stationbus bus
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    6h 28m
    $179–1,459

  9. Bus to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St. Catharines, ON - Bus Terminal to Toronto Union Stationbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    6h 47m
    $379–1,159

St. Catharines to Chicago by train

Calendar7Weekly Trains
Duration14h 1mAverage Duration
Ticket$152Cheapest Price
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Questions & Answers

Map of how to get from St. Catharines to Chicago.ExpandLaunch map view
  • Distance: 525.2 mi
  • Duration: 6h 41m

What companies run services between St. Catharines, ON, Canada and Chicago, IL, USA?

You can take a train from St. Catharines to Chicago Union Station via Buffalo Depew Station in around 14h 1m. Alternatively, you can take a bus from St. Catharines Fairview Mall to Chicago Bus Station via Niagara Falls, Buffalo, and Cleveland Bus Station in around 15h 30m.

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