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How to get fromSt. Catharines to Chicagoby bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus)

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There are 10 ways to get from St. Catharines to Chicago by bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    6h 22m
    $170–377

  2. Bus via Detroit

    cheapest
    1. Take the bus from Bus Terminal, 70 Carlisle St to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicagobus bus
    17h 32m
    $94–199

  3. Train

    1. Take the train from St. Catharines to Buffalotrain train VIA Rail
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    14h 1m
    $302–597

  4. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    15h 50m
    $102–208

  5. Drive  505.2 mi

    1. Drive from St. Catharines to Chicagocar car 505.2 mi
    8h 30m
    $116–167

  6. Bus to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Bus Terminal, 70 Carlisle St to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    6h 40m
    $209–1,559

  7. Bus to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Bus Terminal, 70 Carlisle St to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    6h 54m
    $379–1,009

  8. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    6h 47m
    $180–367

  9. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    7h 1m
    $134–802

  10. Train to Rochester, fly to Chicago O'Hare International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    7h 25m
    $114–642

St. Catharines to Chicago by train

Calendar7Weekly Trains
Duration14h 1mAverage Duration
Ticket$302Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Catharines to Chicago.ExpandLaunch map view
  • Distance: 524.7 mi
  • Duration: 6h 22m

What companies run services between St. Catharines, ON, Canada and Chicago, IL, USA?

You can take a train from St. Catharines to Chicago Union Station via Buffalo Depew Station in around 14h 1m. Alternatively, you can take a bus from Bus Terminal, 70 Carlisle St to Chicago Bus Station via Bus Terminal, Main Street & Willow Avenue, Portage Road & NF Transportation Center, Ellicott Street & MTC Static, Buffalo, and Cleveland Bus Station in around 15h 50m.

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