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How to get fromSt. Louis Airport (STL) to Knoxvilleby plane, bus (Greyhound), train, bus, rideshare, car, or bus (Flixbus)

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There are 9 ways to get from St. Louis Airport (STL) to Knoxville by plane, bus (Greyhound), train, bus, rideshare, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    4h 16m
    $192–884

  2. Drive 494.2 mi

    cheapest
    1. Drive from St. Louis Airport (STL) to Knoxvillecar car 494.2 mi
    8h 13m
    $91–131

  3. Bus

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    39h 52m
    $335–557

  4. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 11m
    $570–1,096

  5. Airport Transfer

    1. Take the rideshare from St. Louis-STL to Knoxvillerideshare rideshare 494.2 mi
    8h 13m

  6. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Chattanooga Metropolitan Airport (CHA)plane plane STL - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 25m
    $180–915

  7. Fly to Asheville Regional Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Asheville Regional Airport (AVL)plane plane STL - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    5h 53m
    $111–511

  8. Train, bus via Ossining

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    41h 46m
    $526–1,022

  9. Bus via Auburn Gresham

    1. Take the bus from St Louis Bus Station to Chicagobus bus
    2. Take the bus from Chicago to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    45h 31m
    $296–448

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar113Weekly Planes
Duration5h 2mAverage Duration
Ticket$137Cheapest Price
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Questions & Answers

Map of how to get from St. Louis Airport (STL) to Knoxville.ExpandLaunch map view
  • Distance: 417.6 mi
  • Duration: 4h 16m

What companies run services between St. Louis Airport (STL), USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Saint Louis to Knoxville via St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 39h 52m.

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