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How to get fromSt. Louis Airport (STL) to Mayo Clinicby plane, train, bus, rideshare, car, shuttle, bus (Flixbus, Greyhound), or bus (Greyhound)

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There are 9 ways to get from St. Louis Airport (STL) to Mayo Clinic by plane, train, bus, rideshare, car, shuttle, bus (Flixbus, Greyhound), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (RST)plane plane STL - RST
    5h 8m
    $80–484

  2. Train, bus via Madison

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    16h 32m
    $162–322

  3. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    17h 30m
    $236–502

  4. Airport Transfer

    1. Take the rideshare from St. Louis-STL to Mayo Clinicrideshare rideshare 435.9 mi
    7h 57m

  5. Drive 435.9 mi

    1. Drive from St. Louis Airport (STL) to Mayo Cliniccar car 435.9 mi
    7h 57m
    $80–115

  6. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    4h 23m
    $440–965

  7. Fly to Mason City, bus, shuttle

    1. Fly from Lambert–St. Louis International Airport (STL) to Mason City (MCW)plane plane STL - MCW
    2. Take the bus from Mason City to Owatonnabus bus
    3. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    8h 31m
    $113–529

  8. Bus via Chicago

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    16h 58m
    $130–215

  9. Bus

    1. Take the bus from St Louis Bus Station to Des Moinesbus bus
    2. Take the bus from Des Moines to Minneapolis Bus Stationbus bus
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    21h 12m
    $150–250

St. Louis Airport (STL) to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration16h 32mAverage Duration
Ticket$162Cheapest Price
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Questions & Answers

Map of how to get from St. Louis Airport (STL) to Mayo Clinic.ExpandLaunch map view
  • Distance: 383.1 mi
  • Duration: 5h 8m

What companies run services between St. Louis Airport (STL), USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines, and Delta fly from Lambert–St. Louis International Airport (STL) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Saint Louis to Mayo Clinic via St Louis Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 16h 58m.

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