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How to get fromSt. Louis Airport (STL) to Panama City Beachby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak, Flixbus, Greyhound)

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There are 9 ways to get from St. Louis Airport (STL) to Panama City Beach by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak, Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    2h 13m
    $138–537

  2. Fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    3h 7m
    $96–482

  3. Bus

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    21h 39m
    $141–275

  4. Bus, train

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the train from Carbondale to New Orleans Union Passenger Terminaltrain train
    3. Take the bus from New Orleans Bus Station to Mobile Bus Stationbus bus
    4. Take the bus from Mobile Bus Station to Panama City Beach Bus Stationbus bus
    26h 28m
    $260–554

  5. Drive 754.7 mi

    1. Drive from St. Louis Airport (STL) to Panama City Beachcar car 754.7 mi
    13h 53m
    $138–199

  6. Fly to Pensacola International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    2. Take the bus from Pensacola Airport to Panama City Beach Bus Stationbus bus
    5h 14m
    $96–437

  7. Fly to Dothan Regional Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Dothan Regional Airport (DHN)plane plane STL - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama City Beachcar car
    5h 42m
    $107–503

  8. Fly to Tallahassee, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Tallahassee (TLH)plane plane STL - TLH
    2. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    7h 3m
    $168–703

  9. Bus via Atlanta

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    23h
    $146–284

Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) flights

Calendar31Weekly Planes
Duration2h 57mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from St. Louis Airport (STL) to Panama City Beach.ExpandLaunch map view
  • Distance: 653.6 mi
  • Duration: 2h 13m

What companies run services between St. Louis Airport (STL), USA and Panama City Beach, FL, USA?

Southwest Airlines and Delta fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) 4 times a day. Alternatively, you can take a bus from Saint Louis to Panama City Beach via St Louis Bus Station, Nashville Bus Station, Tallahassee, and Panama City Beach Bus Station in around 21h 39m.

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