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How to get fromSt. Louis to Birminghamby plane, bus, bus (Greyhound), train (Amtrak), car, or bus (Flixbus, Amtrak)

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There are 5 ways to get from St. Louis to Birmingham by plane, bus, bus (Greyhound), train (Amtrak), car, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, line 461 bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Detroit (DTW)plane plane STL - DTW
    2. Take the bus from Grand Circus Park to Birminghambus bus
    5h 29m
    $456–956

  2. Bus

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis, IN to Detroit, MIbus bus Cincinnati
    11h 51m
    $66–141

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Troy Amtrak Stationtrain train Wolverine
    12h 17m
    $180–385

  4. Drive 528 mi

    1. Drive from St. Louis to Birminghamcar car 528 mi
    9h 14m
    $97–140

  5. Bus via Chicago

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
    2. Take the bus from Chicago Union Station to Troy Amtrak Stationbus bus Amtrak Thruway Connecting Service
    13h 5m
    $151–224

St. Louis to Birmingham by bus and foot

Calendar7Weekly Services
Duration11h 51mAverage Duration
Ticket$66Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Birmingham.ExpandLaunch map view
  • Distance: 493.5 mi
  • Duration: 5h 29m

What companies run services between St. Louis, MO, USA and Birmingham, MI, USA?

You can take a bus from St Louis Bus Station to Birmingham via Indianapolis, IN, Detroit, MI, and Jefferson & Griswold in around 11h 51m. Alternatively, you can take a train from St. Louis to Troy Amtrak Station via Chicago Union Station in around 12h 17m.

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