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How to get fromSt. Louis to Brooklineby plane, train (Amtrak), bus (Greyhound), car, bus, train, or bus (Greyhound, Flixbus)

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There are 7 ways to get from St. Louis to Brookline by plane, train (Amtrak), bus (Greyhound), car, bus, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Boston Logan Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Boston Logan Airport (BOS)plane plane STL - BOS
    4h 40m
    $372–862

  2. Fly to Theodore Francis Green State Airport, train

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Theodore Francis Green State Airport (PVD)plane plane STL - PVD
    2. Take the train from TF Green Airport to Rugglestrain train
    8h 17m
    $106–468

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Bostontrain train Lake Shore Limited
    27h 49m
    $423–883

  4. Bus via New York

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York, NY - W 42nd Street and 9th Avenue to Boston, MA - Dalton and Belvidere Streetbus bus New York
    29h 50m
    $234–473

  5. Drive 1,146.1 mi

    1. Drive from St. Louis to Brooklinecar car 1,146.1 mi
    20h 27m
    $210–303

  6. Fly to Manchester Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Manchester Airport (MHT)plane plane STL - MHT
    2. Take the bus from Boston Manchester Airport to Bostonbus bus
    8h 47m
    $152–724

  7. Bus

    1. Take the bus from St Louis Bus Station to Newark Penn Stationbus bus Greyhound US0421
    2. Take the bus from Newark Penn Station to Brooklinebus bus FlixBus N2605
    30h 20m
    $195–361

St. Louis to Brookline by train (Amtrak)

Calendar7Weekly Trains
Duration27h 49mAverage Duration
Ticket$423Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Brookline.ExpandLaunch map view
  • Distance: 1,068.1 mi
  • Duration: 4h 40m

What companies run services between St. Louis, MO, USA and Brookline, MA, USA?

American Airlines, Southwest Airlines, and Delta fly from Lambert–St. Louis International Airport (STL) to Boston Logan Airport (BOS) every 4 hours. Alternatively, you can take a train from St. Louis to Boston via Chicago Union Station in around 27h 49m.

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