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How to get fromSt. Louis to Buffaloby plane, bus (Greyhound), train (Amtrak), car, bus, or shuttle

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There are 7 ways to get from St. Louis to Buffalo by plane, bus (Greyhound), train (Amtrak), car, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    6h 11m
    $124–706

  2. Bus via Indianapolis

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis, IN to Toledobus bus
    3. Take the bus from Toledo to Clevelandbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    16h 35m
    $84–235

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 39m
    $217–615

  4. Drive 736.3 mi

    1. Drive from St. Louis to Buffalocar car 736.3 mi
    12h 37m
    $135–195

  5. Fly to Rochester, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)plane plane STL - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 58m
    $190–944

  6. Fly to Toronto Pearson International Airport, shuttle

    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Pearson International Airport (YYZ)plane plane STL - YYZ
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    8h 10m
    $168–546

  7. Bus

    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus Greyhound US0421
    2. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    23h 30m
    $131–351

St. Louis to Buffalo by bus

Calendar7Weekly Buses
Duration16h 35mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Buffalo.ExpandLaunch map view
  • Distance: 696.5 mi
  • Duration: 6h 11m

What companies run services between St. Louis, MO, USA and Buffalo, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from St Louis Bus Station to Buffalo, NY via Indianapolis, IN, Toledo, and Cleveland, OH in around 16h 35m.

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