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How to get fromSt. Louis to Buffalo Depew Stationby plane, train (Amtrak), bus (Greyhound), car, train, shuttle, or bus

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There are 7 ways to get from St. Louis to Buffalo Depew Station by plane, train (Amtrak), bus (Greyhound), car, train, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    5h 2m
    $154–766

  2. Bus

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis, IN to Greyhound Station Cincinnatibus bus
    3. Take the bus from Cincinnati, OH to Buffalo, NYbus bus
    20h 53m
    $99–219

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 18m
    $262–535

  4. Drive 739.4 mi

    1. Drive from St. Louis to Buffalo Depew Stationcar car 739.4 mi
    12h 39m
    $135–195

  5. Fly to Rochester, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)plane plane STL - ROC
    2. Take the train from Rochester to Buffalo Depew Stationtrain train
    7h 23m
    $196–1,034

  6. Fly to Toronto Pearson International Airport, shuttle

    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Pearson International Airport (YYZ)plane plane STL - YYZ
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    7h 4m
    $184–556

  7. Bus, train

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus 2510 / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 37m
    $222–437

St. Louis to Buffalo Depew Station by train (Amtrak)

Calendar14Weekly Trains
Duration16h 18mAverage Duration
Ticket$262Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Buffalo Depew Station.ExpandLaunch map view
  • Distance: 689.3 mi
  • Duration: 5h 2m

What companies run services between St. Louis, MO, USA and Buffalo Depew Station, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a train from St. Louis to Buffalo Depew Station via Chicago Union Station in around 16h 18m.

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