Rome2Rio

How to get fromSt. Louis to Cairoby plane, taxi, bus (Amtrak, Flixbus, Greyhound), car, or bus (Greyhound, Flixbus)

Find Transport to Cairo

See all options

There are 7 ways to get from St. Louis to Cairo by plane, taxi, bus (Amtrak, Flixbus, Greyhound), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Tallahassee, taxi

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Tallahassee (TLH)plane plane STL - TLH
    2. Take the taxi from Tallahassee (TLH) to Cairotaxi taxi
    6h 2m
    $242–762

  2. Fly to Southwest Georgia Regional Airport, drive

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Southwest Georgia Regional Airport (ABY)plane plane STL - ABY
    2. Drive from Southwest Georgia Regional Airport (ABY) to Cairocar car
    6h 19m
    $86–458

  3. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Thomasville Travel Centerbus bus
    17h 36m
    $160–252

  4. Drive  753.4 mi

    1. Drive from St. Louis to Cairocar car 753.4 mi
    13h 23m
    $138–199

  5. Fly to Valdosta, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Valdosta (VLD)plane plane STL - VLD
    2. Drive from Valdosta (VLD) to Cairocar car
    6h 44m
    $92–468

  6. Fly to Northwest Florida Beaches International Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    2. Drive from Northwest Florida Beaches International Airport (ECP) to Cairocar car
    6h
    $100–478

  7. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Thomasville Travel Centerbus bus FlixBus 2452
    18h 11m
    $167–266

Lambert–St. Louis International Airport (STL) to Tallahassee (TLH) flights

Calendar71Weekly Planes
Duration5h 29mAverage Duration
Ticket$110Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from St. Louis to Cairo.ExpandLaunch map view
  • Distance: 723.8 mi
  • Duration: 6h 2m

What companies run services between St. Louis, MO, USA and Cairo, GA, USA?

You can take a bus from St. Louis to Cairo via Carbondale Intermodal Station, Atlanta Bus Station, and Thomasville Travel Center in around 17h 36m.

Airlines
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There