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How to get fromSt. Louis to Carlisleby plane, bus (Greyhound), train (Amtrak), car, or train

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There are 5 ways to get from St. Louis to Carlisle by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Harrisburg International Airport (MDT)plane plane STL - MDT
    8h 10m
    $104–556

  2. Bus (Greyhound)

    1. Take the bus from St Louis Bus Station to Harrisburg Bus Stationbus bus Greyhound US0421
    21h 11m
    $123–231

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    3. Take the train from Pittsburgh Amtrak Station to Harrisburgtrain train
    23h 35m
    $316–677

  4. Drive 764.9 mi

    1. Drive from St. Louis to Carlislecar car 764.9 mi
    13h 7m
    $140–202

  5. Fly to Philadelphia International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Philadelphia International Airport (PHL)plane plane STL - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    9h 3m
    $186–878

St. Louis to Carlisle by bus and foot (Greyhound)

Calendar42Weekly Services
Duration21h 11mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Carlisle.ExpandLaunch map view
  • Distance: 776.7 mi
  • Duration: 8h 10m

What companies run services between St. Louis, MO, USA and Carlisle, PA, USA?

Delta, American Airlines, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Harrisburg International Airport (MDT) hourly. Alternatively, Greyhound USA operates a bus from St Louis Bus Station to Harrisburg Bus Station every 4 hours. Tickets cost $120–230 and the journey takes 19h 20m.

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