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How to get fromSt. Louis to Chapel Hillby plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, or bus (Greyhound)

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There are 6 ways to get from St. Louis to Chapel Hill by plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Raleigh-Durham International Airport, bus, line 800 bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)plane plane STL - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Pittsboro St at Credit Unionbus bus
    5h 3m
    $558–1,008

  2. Drive 749.6 mi

    cheapest
    1. Drive from St. Louis to Chapel Hillcar car 749.6 mi
    13h 42m
    $137–198

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus FlixBus N2521
    2. Take the bus from Atlanta Bus Station to Durhambus bus FlixBus N2471 / ...
    19h 33m
    $150–286

  4. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Carytrain train Floridian
    32h 18m
    $447–889

  5. Fly to Piedmont Triad International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO)plane plane STL - GSO
    2. Take the bus from Coble Transportation Center to N Columbia St at W Franklin Stbus bus
    8h 24m
    $172–876

  6. Bus via Columbus

    1. Take the bus from St Louis Bus Station to Columbusbus bus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Coble Transportation Center to N Columbia St at W Franklin Stbus bus 4
    23h 48m
    $138–263

St. Louis to Chapel Hill by bus

Calendar19Weekly Buses
Duration19h 33mAverage Duration
Ticket$150Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Chapel Hill.ExpandLaunch map view
  • Distance: 698.4 mi
  • Duration: 5h 3m

What companies run services between St. Louis, MO, USA and Chapel Hill, Orange County, NC, USA?

You can take a bus from St Louis Bus Station to E Franklin St at Varsity Theatre via Atlanta Bus Station, Durham, and Durham Station in around 19h 33m. Alternatively, you can take a train from St. Louis to South Rd at Kenan Labs via Chicago Union Station, Cary, Cary Depot, and Regional Transit Center in around 32h 18m.

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