There are 4 ways to get from St. Louis to Charleston by plane, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Charleston International Airport
best- Fly from Lambert–St. Louis International Airport (STL) to Charleston International Airport (CHS)plane STL - CHS
5h$104–554Bus
- Take the bus from St Louis Bus Station to Atlanta Bus Stationbus FlixBus N2521
- Take the bus from Atlanta Bus Station to Charleston Bus Stationbus Greyhound US0641S
24h 39m$161–308Drive 839.4 mi
- Drive from St. Louis to Charlestoncar 839.4 mi
14h 38m$154–222Fly to Hilton Head Airport, drive
- Fly from Lambert–St. Louis International Airport (STL) to Hilton Head Airport (HHH)plane STL - HHH
- Drive from Hilton Head Airport (HHH) to Charlestoncar
7h 46m$120–530
St. Louis to Charleston by bus
Questions & Answers
The cheapest way to get from St. Louis to Charleston is to drive which costs $150 - $230 and takes 14h 38m.
The fastest way to get from St. Louis to Charleston is to fly which takes 5h and costs $100 - $600.
No, there is no direct bus from St. Louis station to Charleston. However, there are services departing from St Louis Bus Station and arriving at Transit Mall via Atlanta Bus Station, North Charleston Transit Center and Rivers Ave / Cosgrove Ave. The journey, including transfers, takes approximately 24h 39m.
The distance between St. Louis and Charleston is 738 miles. The road distance is 844.3 miles.
The best way to get from St. Louis to Charleston without a car is to bus which takes 24h 39m and costs $160 - $310.
It takes approximately 5h to get from St. Louis to Charleston, including transfers.
St. Louis to Charleston bus services, operated by FlixBus-us, depart from St Louis Bus Station.
The best way to get from St. Louis to Charleston is to fly which takes 5h and costs $100 - $600. Alternatively, you can bus, which costs $160 - $310 and takes 24h 39m.
St. Louis to Charleston bus services, operated by FlixBus-us, arrive at Atlanta Bus Station.
Charleston is 1h ahead of St. Louis. It is currently 2:37 PM in St. Louis and 3:37 PM in Charleston.
What companies run services between St. Louis, MO, USA and Charleston, SC, USA?
Southwest Airlines, Delta, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Charleston International Airport (CHS) every 4 hours. Alternatively, you can take a bus from St Louis Bus Station to Transit Mall via Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 24h 39m.
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Charleston International Airport via Charlotte
- Ave. Duration
- 4h 12m
- When
- Every day
- Estimated price
- $110–550
Flights from Lambert–St. Louis International Airport to Hilton Head Airport via Charlotte
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $100–550
Flights from Lambert–St. Louis International Airport to Hilton Head Airport via Chicago O'Hare
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $130–600
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Charleston International Airport
- Ave. Duration
- 1h 58m
- When
- Sunday, Saturday, Monday, Thursday, and Friday
- Estimated price
- $100–550
Flights from Lambert–St. Louis International Airport to Charleston International Airport via Chicago Midway
- Ave. Duration
- 4h 28m
- When
- Monday, Thursday, Friday, Tuesday, Wednesday, and Sunday
- Estimated price
- $130–650
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Charleston International Airport via Atlanta
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $110–550
Flights from Lambert–St. Louis International Airport to Hilton Head Airport via Atlanta
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $100–500
- Website
- united.com
Flights from Lambert–St. Louis International Airport to Hilton Head Airport via Chicago O'Hare
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $130–600
- Website
- flixbus.com
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 10h 30m
- Frequency
- Once daily
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Once daily
- Estimated price
- $85–170
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Charleston Bus Station
- Ave. Duration
- 11h 20m
- Frequency
- Once daily
- Estimated price
- $70–140
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 10h
- Frequency
- 5 times a week
- Estimated price
- $85–150
- Schedules at
- flixbus.com
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More Questions & Answers
Yes, the driving distance between St. Louis to Charleston is 844 miles. It takes approximately 14h 38m to drive from St. Louis to Charleston.
Book your St. Louis to Charleston bus tickets online with Omio.
There are 1678+ hotels available in Charleston.