There are 7 ways to get from St. Louis to Chicago Bus Station by train (Amtrak), bus (Flixbus), car, plane, train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from St. Louis to Chicago Union Stationtrain Lincoln Service / ...
5h 4m$90–190Bus
cheapest- Take the bus from St Louis Bus Station to Chicago Bus Stationbus FlixBus 2510 / ...
6h 5m$50–85Drive 292.1 mi
- Drive from St. Louis to Chicago Bus Stationcar 292.1 mi
5h 3m$54–77Fly Lambert–St. Louis International Airport to Chicago Midway International Airport
- Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane STL - MDW
3h 32m$60–368Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane STL - ORD
3h 52m$274–708Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport
- Take the train from St. Louis to Springfieldtrain
- Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane SPI - ORD
5h 2m$76–304Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport
- Take the bus from St. Louis to Carbondalebus
- Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane MWA - ORD
5h 53m$132–311
St. Louis to Chicago Bus Station by train and foot (Amtrak)
Questions & Answers
The cheapest way to get from St. Louis to Chicago Bus Station is to bus which costs $50 - $85 and takes 6h 5m.
The fastest way to get from St. Louis to Chicago Bus Station is to fly which takes 3h 32m and costs $55 - $370.
Yes, there is a direct bus departing from St Louis Bus Station station and arriving at Chicago Bus Station station. Services depart three times a day, and operate every day. The journey takes approximately 6h 5m.
Yes, there is a direct train departing from St. Louis and arriving at Chicago Union Station station. Services depart five times a day, and operate every day. The journey takes approximately 4h 55m.
The distance between St. Louis and Chicago Bus Station is 283 miles. The road distance is 293.8 miles.
The best way to get from St. Louis to Chicago Bus Station without a car is to train which takes 5h 4m and costs $90 - $190.
The train from St. Louis to Chicago Union Station takes 4h 55m including transfers and departs five times a day.
St. Louis to Chicago Bus Station bus services, operated by Jefferson Lines, depart from St Louis Bus Station.
St. Louis to Chicago Bus Station train services, operated by Amtrak, depart from St. Louis station.
The best way to get from St. Louis to Chicago Bus Station is to train which takes 5h 4m and costs $90 - $190. Alternatively, you can bus, which costs $50 - $85 and takes 6h 5m, you could also fly, which costs $55 - $370 and takes 3h 32m.
What companies run services between St. Louis, MO, USA and Chicago Bus Station, IL, USA?
Amtrak operates a train from St. Louis to Chicago Union Station 5 times a day. Tickets cost $90–190 and the journey takes 4h 55m. Alternatively, Jefferson Lines operates a bus from St Louis Bus Station to Chicago Bus Station 3 times a day. Tickets cost $75–110 and the journey takes 6h 5m. Flixbus USA also services this route twice daily.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- $55–360
- Website
- united.com
Flights from Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $45–310
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $45–310
Flights from Abraham Lincoln Capital Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $30–220
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 44m
- When
- Every day
- Estimated price
- $40–280
- Website
- contouraviation.com
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $85–220
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from St. Louis to Chicago Union Station
- Ave. Duration
- 4h 55m
- Frequency
- 5 times a day
- Estimated price
- $90–190
- Website
- https://www.amtrak.com/home.html
Train from St. Louis to Springfield
- Ave. Duration
- 1h 38m
- Frequency
- 5 times a day
- Estimated price
- $30–65
- Website
- https://www.amtrak.com/home.html
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from St Louis Bus Station to Chicago Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- 3 times a day
- Estimated price
- $75–110
- Book at
- https://www.jeffersonlines.com
- Adult
- $75–110
Bus from St. Louis to Carbondale
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $30–45
- Book at
- https://www.jeffersonlines.com
- Adult
- $30–45
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from St Louis Bus Station to Chicago Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- Twice daily
- Estimated price
- $50–85
- Schedules at
- flixbus.com
Bus from St. Louis to Carbondale
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- $15–26
- Schedules at
- flixbus.com
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from St. Louis to Carbondale
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
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More Questions & Answers
St. Louis to Chicago Bus Station bus services, operated by Jefferson Lines, arrive at Chicago Bus Station.
St. Louis to Chicago Bus Station train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between St. Louis to Chicago Bus Station is 294 miles. It takes approximately 5h 3m to drive from St. Louis to Chicago Bus Station.
Book your St. Louis to Chicago Bus Station train tickets online with Omio.
Book your St. Louis to Chicago Bus Station bus tickets online with Omio and FlixBus.
There are 1295+ hotels available in Chicago Bus Station.