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How to get fromSt. Louis to Cleveland, OHby plane, bus, bus (Greyhound), train (Amtrak), or car

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There are 5 ways to get from St. Louis to Cleveland, OH by plane, bus, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, line 9 bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Cleveland-Hopkins International Airport (CLE)plane plane STL - CLE
    2. Take the bus from Prospect Av & W 3Rd St to Payne Av & E 30Th Stbus bus
    4h 6m
    $498–908

  2. Bus via Indianapolis

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis, IN to Toledobus bus
    3. Take the bus from Toledo to Clevelandbus bus
    12h 22m
    $72–184

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Cleveland Amtraktrain train Floridian / ...
    12h 37m
    $205–417

  4. Drive 553.6 mi

    1. Drive from St. Louis to Cleveland, OHcar car 553.6 mi
    9h 25m
    $101–146

  5. Bus

    1. Take the bus from St Louis Bus Station to Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus, Ohio Greyhound Station to Cleveland Ohio Greyhound Stationbus bus 374 D
    16h 16m
    $127–208

St. Louis to Cleveland, OH by bus and foot

Calendar7Weekly Services
Duration12h 22mAverage Duration
Ticket$72Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Cleveland, OH.ExpandLaunch map view
  • Distance: 514.3 mi
  • Duration: 4h 6m

What companies run services between St. Louis, MO, USA and Cleveland, OH, USA?

You can take a bus from St Louis Bus Station to Cleveland, OH via Indianapolis, IN, Toledo, and Cleveland in around 12h 22m. Alternatively, you can take a train from St. Louis to Cleveland, OH via Chicago Union Station, Cleveland Amtrak, St. Clair Av & W Mall Dr, and St. Clair Av & E 30Th St in around 12h 37m.

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