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How to get fromSt. Louis to Columbiaby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, bus, or bus (Greyhound)

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There are 7 ways to get from St. Louis to Columbia by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Columbia (CAE)plane plane STL - CAE
    6h 44m
    $234–1,204

  2. Drive 743.1 mi

    cheapest
    1. Drive from St. Louis to Columbiacar car 743.1 mi
    12h 29m
    $136–196

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta to Camdenbus bus
    3. Take the bus from Camden to Columbia, SCbus bus Nyc
    18h 51m
    $149–275

  4. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Columbia Stationtrain train Floridian
    34h 40m
    $502–1,035

  5. Fly to Savannah, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Savannah (SAV)plane plane STL - SAV
    2. Take the train from Savannah Station to Columbia Stationtrain train
    7h 7m
    $218–848

  6. Fly to Augusta Regional Airport At Bush Field, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Augusta Regional Airport At Bush Field (AGS)plane plane STL - AGS
    2. Take the bus from Augusta to Columbia, SCbus bus
    8h 48m
    $154–564

  7. Bus via Evansville

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Camdenbus bus
    4. Take the bus from Camden to Columbia, SCbus bus Nyc
    20h 46m
    $150–285

St. Louis to Columbia by train (Amtrak)

Calendar7Weekly Trains
Duration34h 40mAverage Duration
Ticket$502Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Columbia.ExpandLaunch map view
  • Distance: 634.2 mi
  • Duration: 6h 44m

What companies run services between St. Louis, MO, USA and Columbia, SC, USA?

American Airlines, Delta, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Columbia (CAE) hourly. Alternatively, you can take a bus from St Louis Bus Station to Sumter Laurel South via Atlanta, Camden, Columbia, SC, and Broad Marley South in around 18h 51m.

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