There are 7 ways to get from St. Louis to DePaul University by train (Amtrak), bus (Flixbus), car, plane, subway, train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from St. Louis to Chicago Union Stationtrain Lincoln Service / ...
5h 32m$71–165Bus (Flixbus)
cheapest- Take the bus from St Louis Bus Station to Chicago Bus Stationbus FlixBus N2521 / ...
6h 57m$51–75Drive 294.6 mi
- Drive from St. Louis to DePaul Universitycar 294.6 mi
5h 9m$54–78Fly Lambert–St. Louis International Airport to Chicago Midway International Airport, subway
- Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane STL - MDW
- Take the subway from Roosevelt to Fullertonsubway
3h 39m$56–362Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport, subway
- Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane STL - ORD
- Take the subway from Lake to Fullertonsubway
4h$326–712Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport
- Take the train from St. Louis to Springfieldtrain
- Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane SPI - ORD
5h 4m$70–311Bus to Decatur Airport, fly to Chicago O'Hare International Airport
- Take the bus from St Louis Bus Station to Decatur Downtown Transportation Centerbus
- Fly from Decatur Airport (DEC) to Chicago O'Hare International Airport (ORD)plane DEC - ORD
5h 54m$68–287
St. Louis to DePaul University by train, foot, and subway (Amtrak)
Comparing Your Travel Options
The cheapest way to get from St. Louis to DePaul University is to bus which costs $50 - $75 and takes 6h 57m.
The fastest way to get from St. Louis to DePaul University is to fly and subway which takes 3h 39m and costs $55 - $370.
No, there is no direct bus from St. Louis station to DePaul University. However, there are services departing from St Louis Bus Station and arriving at Webster & Bissell via Jefferson & Harrison. The journey, including transfers, takes approximately 6h 57m.
No, there is no direct train from St. Louis to DePaul University. However, there are services departing from St. Louis and arriving at Fullerton via LaSalle/Van Buren. The journey, including transfers, takes approximately 5h 32m.
The distance between St. Louis and DePaul University is 288 miles. The road distance is 296.3 miles.
The best way to get from St. Louis to DePaul University without a car is to train which takes 5h 32m and costs $70 - $170.
It takes approximately 5h 32m to get from St. Louis to DePaul University, including transfers.
St. Louis to DePaul University bus services, operated by Flixbus USA, depart from St Louis Bus Station.
St. Louis to DePaul University train services, operated by Amtrak, depart from St. Louis station.
The best way to get from St. Louis to DePaul University is to train which takes 5h 32m and costs $70 - $170. Alternatively, you can bus, which costs $50 - $75 and takes 6h 57m.
What companies run services between St. Louis, MO, USA and DePaul University, IL, USA?
Amtrak operates a train from St. Louis to Chicago Union Station 5 times a day. Tickets cost $65–160 and the journey takes 4h 55m. Alternatively, Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station twice daily. Tickets cost $45–75 and the journey takes 6h 5m.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- $50–350
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from St. Louis to Chicago Union Station
- Ave. Duration
- 4h 55m
- Frequency
- 5 times a day
- Estimated price
- $65–160
- Website
- Amtrak
Train from St. Louis to Springfield
- Ave. Duration
- 1h 38m
- Frequency
- 5 times a day
- Estimated price
- $23–55
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from St Louis Bus Station to Chicago Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- Twice daily
- Estimated price
- $45–75
- Schedules at
- Flixbus USA
Bus from St Louis Bus Station to Decatur Downtown Transportation Center
- Ave. Duration
- 2h 35m
- Frequency
- 5 times a week
- Estimated price
- $20–35
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
St. Louis to DePaul University bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
St. Louis to DePaul University train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between St. Louis to DePaul University is 296 miles. It takes approximately 5h 9m to drive from St. Louis to DePaul University.
There are 1280+ hotels available in DePaul University.