What is the cheapest way to get from St. Louis to Des Moines?

The cheapest way to get from St. Louis to Des Moines is to drive which costs $55 - $85 and takes 6h 35m.

What is the fastest way to get from St. Louis to Des Moines?

The fastest way to get from St. Louis to Des Moines is to fly which takes 5h 33m and costs $90 - $460.

Is there a direct bus between St. Louis and Des Moines?

No, there is no direct bus from St. Louis station to Des Moines. However, there are services departing from St Louis Bus Station and arriving at Des Moines via Kansas City. The journey, including transfers, takes approximately 8h 25m.

How far is it from St. Louis to Des Moines?

The distance between St. Louis and Des Moines is 444 miles. The road distance is 333.1 miles.

How do I travel from St. Louis to Des Moines without a car?

The best way to get from St. Louis to Des Moines without a car is to bus via Kansas City which takes 8h 25m and costs $95 - $150.

How long does it take to get from St. Louis to Des Moines?

It takes approximately 8h 25m to get from St. Louis to Des Moines, including transfers.

Where do I catch the St. Louis to Des Moines bus from?

St. Louis to Des Moines bus services, operated by Greyhound USA, depart from St Louis Bus Station.

Bus or fly from St. Louis to Des Moines?

The best way to get from St. Louis to Des Moines is to bus via Kansas City which takes 8h 25m and costs $95 - $150. Alternatively, you can fly, which costs $90 - $460 and takes 5h 33m.

Where does the St. Louis to Des Moines bus arrive?

St. Louis to Des Moines bus services, operated by Greyhound USA, arrive at Kansas City Bus Station.

Can I drive from St. Louis to Des Moines?

Yes, the driving distance between St. Louis to Des Moines is 333 miles. It takes approximately 6h 35m to drive from St. Louis to Des Moines.

How do I get a bus ticket from St. Louis to Des Moines?

Book your St. Louis to Des Moines bus tickets online with Omio.

Where can I stay near Des Moines?

There are 239+ hotels available in Des Moines.

St. Louis to Des Moines - 7 ways to travel via train, bus, car, and plane

How to get fromSt. Louis to Des Moines

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There are 7 ways to get from St. Louis to Des Moines by bus (Greyhound), train, bus, car, plane, or bus (Flixbus, Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus via Kansas City
best
1. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus Greyhound US0180s / ...
2. Take the bus from Kansas City to Des Moinesbus Jefferson Lines 804 / ...
8h 25m
$95–141
Drive 331.1 mi
cheapest
1. Drive from St. Louis to Des Moinescar 331.1 mi
6h 35m
$57–82
Train, bus via Kansas City
1. Take the train from St. Louis to Kansas Citytrain Missouri River Runner / ...
2. Take the bus from Kansas City Bus Station to Des Moinesbus Greyhound US0156
10h 37m
$188–290
Fly from Lambert–St. Louis International Airport
1. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane STL - DSM
5h 33m
$90–456
Train, bus
1. Take the train from St. Louis to Bloomington-Normaltrain Lincoln Service / ...
2. Take the bus from Bloomington-Normal to Des Moinesbus Greyhound US0157S
10h 3m
$136–212
Bus
1. Take the bus from St Louis Bus Station to Springfield SMTD Transfer Centerbus
2. Take the bus from Springfield to Galesburg Amtrak Stationbus
3. Take the bus from Galesburg to Des Moinesbus
11h 31m
Train to Abraham Lincoln Capital Airport, fly
1. Take the train from St. Louis to Springfieldtrain
2. Fly from Abraham Lincoln Capital Airport (SPI) to Des Moines (DSM)plane SPI - DSM
10h 22m
$144–480

St. Louis to Des Moines by bus

18Weekly Buses

8h 25mAverage Duration

$95Cheapest Price

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Comparing Your Travel Options

Map of how to get from St. Louis to Des Moines.

Launch map view

Distance: 441.6 mi
Duration: 8h 25m

What companies run services between St. Louis, MO, USA and Des Moines, IA, USA?

You can take a bus from St Louis Bus Station to Des Moines via Kansas City Bus Station and Kansas City in around 8h 25m. Alternatively, Delta, United Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM) hourly.

Airlines

Train operators

Bus operators

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