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How to get fromSt. Louis to Des Moinesby bus (Greyhound), car, plane, or train

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There are 4 ways to get from St. Louis to Des Moines by bus (Greyhound), car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from St Louis Bus Station to Des Moinesbus bus Greyhound US0153S
    8h 30m
    $60–120

  2. Drive 331.1 mi

    1. Drive from St. Louis to Des Moinescar car 331.1 mi
    6h 35m
    $61–88

  3. Fly from Lambert–St. Louis International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane plane STL - DSM
    5h 22m
    $150–774

  4. Train to Abraham Lincoln Capital Airport, fly

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Des Moines (DSM)plane plane SPI - DSM
    6h 46m
    $153–647

St. Louis to Des Moines by bus (Greyhound)

Calendar7Weekly Buses
Duration8h 30mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Des Moines.ExpandLaunch map view
  • Distance: 416.2 mi
  • Duration: 8h 30m

What companies run services between St. Louis, MO, USA and Des Moines, IA, USA?

Greyhound USA operates a bus from St Louis Bus Station to Des Moines once daily. Tickets cost $60–120 and the journey takes 8h 30m. Alternatively, Southwest Airlines, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM) hourly.

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