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How to get fromSt. Louis to Des Moinesby bus (Greyhound), train, bus, car, plane, or bus (Flixbus, Amtrak, Greyhound)

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There are 7 ways to get from St. Louis to Des Moines by bus (Greyhound), train, bus, car, plane, or bus (Flixbus, Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Kansas City

    best
    1. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus Greyhound US0180s / ...
    2. Take the bus from Kansas City to Des Moinesbus bus Jefferson Lines 804 / ...
    8h 25m
    $90–151

  2. Drive  331.1 mi

    cheapest
    1. Drive from St. Louis to Des Moinescar car 331.1 mi
    6h 35m
    $61–88

  3. Train, bus via Kansas City

    1. Take the train from St. Louis to Kansas Citytrain train Missouri River Runner / ...
    2. Take the bus from Kansas City Bus Station to Des Moinesbus bus Greyhound US0156
    10h 37m
    $105–225

  4. Fly from Lambert–St. Louis International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane plane STL - DSM
    5h 22m
    $140–774

  5. Train, bus

    1. Take the train from St. Louis to Bloomington-Normaltrain train Lincoln Service / ...
    2. Take the bus from Bloomington-Normal to Des Moinesbus bus Greyhound US0157S
    10h 8m
    $87–183

  6. Bus

    1. Take the bus from St Louis Bus Station to Springfield SMTD Transfer Centerbus bus
    2. Take the bus from Springfield to Galesburg Amtrak Stationbus bus
    3. Take the bus from Galesburg to Des Moinesbus bus
    11h 31m
    $81–145

  7. Train to Abraham Lincoln Capital Airport, fly

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Des Moines (DSM)plane plane SPI - DSM
    7h 28m
    $156–694

St. Louis to Des Moines by bus

Calendar18Weekly Buses
Duration8h 25mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Des Moines.ExpandLaunch map view
  • Distance: 441.6 mi
  • Duration: 8h 25m

What companies run services between St. Louis, MO, USA and Des Moines, IA, USA?

You can take a bus from St Louis Bus Station to Des Moines via Kansas City Bus Station and Kansas City in around 8h 25m. Alternatively, Southwest Airlines, United Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM) hourly.

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