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How to get fromSt. Louis to Des Plainesby plane, train (Amtrak), train, bus, car, or bus (Flixbus)

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There are 10 ways to get from St. Louis to Des Plaines by plane, train (Amtrak), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    3h 32m
    $324–758

  2. Bus (Flixbus)

    cheapest
    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
    9h
    $52–81

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    6h 5m
    $83–174

  4. Train, bus

    1. Take the train from St. Louis to Bloomington-Normaltrain train Lincoln Service / ...
    2. Take the bus from Uptown Station to Woodfield Mallbus bus Peoria line
    7h 45m
    $89–156

  5. Drive  295.8 mi

    1. Drive from St. Louis to Des Plainescar car 295.8 mi
    5h 7m
    $54–78

  6. Fly Lambert–St. Louis International Airport to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago OTC to Des Plainestrain train
    4h 32m
    $58–362

  7. Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane plane SPI - ORD
    4h 38m
    $70–368

  8. Bus to Decatur Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St Louis Bus Station to Decatur Downtown Transportation Centerbus bus
    2. Fly from Decatur Airport (DEC) to Chicago O'Hare International Airport (ORD)plane plane DEC - ORD
    5h 21m
    $65–344

  9. Fly Lambert–St. Louis International Airport to General Mitchell International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane plane STL - MKE
    2. Take the bus from Mitchell Airport to O'Hare International Airport - Terminal 2 Departuresbus bus
    5h 29m
    $518–946

  10. Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    5h 32m
    $125–356

St. Louis to Des Plaines by train, foot, and bus (Amtrak)

Calendar38Weekly Services
Duration6h 5mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Des Plaines.ExpandLaunch map view
  • Distance: 275.4 mi
  • Duration: 3h 32m

What companies run services between St. Louis, MO, USA and Des Plaines, IL, USA?

American Airlines and United Airlines fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, Amtrak operates a train from St. Louis to Chicago Union Station 5 times a day. Tickets cost $75–170 and the journey takes 4h 55m.

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Train operators
Bus operators

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