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How to get fromSt. Louis to Detroit, MIby plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

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There are 6 ways to get from St. Louis to Detroit, MI by plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Detroit

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Detroit (DTW)plane plane STL - DTW
    4h 34m
    $404–954

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Detroit Bus Stationbus bus Greyhound US0112
    11h 10m
    $78–150

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Detroittrain train Wolverine
    11h 48m
    $184–375

  4. Drive 516.7 mi

    1. Drive from St. Louis to Detroit, MIcar car 516.7 mi
    8h 51m
    $95–137

  5. Fly to Cleveland-Hopkins International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Cleveland-Hopkins International Airport (CLE)plane plane STL - CLE
    2. Take the bus from Cleveland Bus Station to Detroit Bus Stationbus bus
    7h 40m
    $520–956

  6. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from St Louis Bus Station to Chicagobus bus FlixBus N2521
    2. Take the bus from Chicago to Detroit Bus Stationbus bus FlixBus 2552
    14h 20m
    $97–168

St. Louis to Detroit, MI by bus (Greyhound)

Calendar7Weekly Buses
Duration11h 10mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Detroit, MI.ExpandLaunch map view
  • Distance: 476.1 mi
  • Duration: 4h 34m

What companies run services between St. Louis, MO, USA and Detroit, MI, USA?

Delta and Southwest Airlines fly from Lambert–St. Louis International Airport (STL) to Detroit (DTW) every 4 hours. Alternatively, you can take a bus from St Louis Bus Station to Detroit Bus Station via Indianapolis Union Station in around 11h 10m.

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Need to know: Greyhound

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