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How to get fromSt. Louis to Durhamby plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, or train

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There are 5 ways to get from St. Louis to Durham by plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Raleigh-Durham International Airport, bus, line 700 bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)plane plane STL - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    4h 44m
    $108–608

  2. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus FlixBus N2521
    2. Take the bus from Atlanta Bus Station to Durhambus bus FlixBus N2471 / ...
    18h 20m
    $148–255

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Durham Amtrak Stationtrain train
    31h 26m
    $719–1,209

  4. Drive  755.9 mi

    1. Drive from St. Louis to Durhamcar car 755.9 mi
    13h 45m
    $138–200

  5. Fly to Piedmont Triad International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO)plane plane STL - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    7h 28m
    $142–538

St. Louis to Durham by bus

Calendar12Weekly Buses
Duration18h 20mAverage Duration
Ticket$148Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Durham.ExpandLaunch map view
  • Distance: 696.4 mi
  • Duration: 4h 44m

What companies run services between St. Louis, MO, USA and Durham, NC, USA?

You can take a bus from St Louis Bus Station to Durham via Atlanta Bus Station in around 18h 20m. Alternatively, you can take a train from St. Louis to Durham Amtrak Station via Chicago Union Station and Raleigh Union Station in around 31h 26m.

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