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How to get fromSt. Louis to Florenceby plane, bus (Flixbus, Amtrak, Greyhound), train (Amtrak), car, bus, or bus (Greyhound, Flixbus)

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There are 6 ways to get from St. Louis to Florence by plane, bus (Flixbus, Amtrak, Greyhound), train (Amtrak), car, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Florence Regional Airport (FLO)plane plane STL - FLO
    6h 35m
    $98–476

  2. Bus via Carbondale

    1. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    18h 25m
    $140–218

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Florence Stationtrain train
    33h 4m
    $795–1,268

  4. Drive  820.1 mi

    1. Drive from St. Louis to Florencecar car 820.1 mi
    13h 48m
    $145–210

  5. Fly to Myrtle Beach, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Myrtle Beach (MYR)plane plane STL - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 7m
    $106–466

  6. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus Greyhound US0641S / ...
    19h
    $145–239

St. Louis to Florence by bus

Calendar10Weekly Buses
Duration18h 25mAverage Duration
Ticket$140Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Florence.ExpandLaunch map view
  • Distance: 685 mi
  • Duration: 6h 35m

What companies run services between St. Louis, MO, USA and Florence, SC, USA?

American Airlines and Southwest Airlines fly from Lambert–St. Louis International Airport (STL) to Florence Regional Airport (FLO) twice daily. Alternatively, you can take a bus from St Louis Bus Station to Florence Bus Station via Carbondale Intermodal Station and Atlanta Bus Station in around 18h 25m.

Airlines
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Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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Need to know: Greyhound

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