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How to get fromSt. Louis to Florida Panhandleby plane, car, or bus

Find Transport to Florida Panhandle

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There are 8 ways to get from St. Louis to Florida Panhandle by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Northwest Florida Beaches International Airport, drive

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    2. Drive from Northwest Florida Beaches International Airport (ECP) to Florida Panhandlecar car
    4h 44m
    $88–458

  2. Bus, drive

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Drive from Tallahassee to Florida Panhandlecar car
    18h 6m
    $139–228

  3. Drive  746.6 mi

    1. Drive from St. Louis to Florida Panhandlecar car 746.6 mi
    13h 28m
    $137–197

  4. Fly Lambert–St. Louis International Airport to Tallahassee, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Tallahassee (TLH)plane plane STL - TLH
    2. Drive from Tallahassee (TLH) to Florida Panhandlecar car
    6h 24m
    $122–618

  5. Fly Lambert–St. Louis International Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Florida Panhandlecar car
    5h 28m
    $96–460

  6. Fly Lambert–St. Louis International Airport to Dothan Regional Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Dothan Regional Airport (DHN)plane plane STL - DHN
    2. Drive from Dothan Regional Airport (DHN) to Florida Panhandlecar car
    6h 59m
    $96–464

  7. Fly Midamerica St. Louis Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Florida Panhandlecar car
    5h 46m
    $108–438

  8. Bus, drive via Atlanta

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    3. Drive from Capital Circle NW and Commonwealth Boulevard to Florida Panhandlecar car
    21h 8m
    $139–238

Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) flights

Calendar32Weekly Planes
Duration3h 1mAverage Duration
Ticket$79Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Florida Panhandle.ExpandLaunch map view
  • Distance: 705.6 mi
  • Duration: 4h 44m

What companies run services between St. Louis, MO, USA and Florida Panhandle, FL, USA?

There is no direct connection from St. Louis to Florida Panhandle. However, you can take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Northwest Florida Beaches International Airport (ECP), then drive to Florida Panhandle. Alternatively, you can take a bus from St Louis Bus Station to Florida Panhandle via Nashville Bus Station and Tallahassee in around 18h 6m.

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