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How to get fromSt. Louis to Fort Wayneby plane, bus, bus (Greyhound), train (Amtrak), car, or bus (Flixbus)

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There are 8 ways to get from St. Louis to Fort Wayne by plane, bus, bus (Greyhound), train (Amtrak), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Detroit, line 41 bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Detroit (DTW)plane plane STL - DTW
    2. Take the bus from Schaefer & Michigan to Jefferson & Brennanbus bus
    5h 35m
    $458–958

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Detroit Bus Stationbus bus Greyhound US0112
    11h 49m
    $79–157

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Detroittrain train Wolverine
    12h 19m
    $184–379

  4. Drive 513.1 mi

    1. Drive from St. Louis to Fort Waynecar car 513.1 mi
    8h 50m
    $94–136

  5. Fly to Windsor Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Windsor Airport (YQG)plane plane STL - YQG
    8h 18m
    $154–756

  6. Fly to Cleveland-Hopkins International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Cleveland-Hopkins International Airport (CLE)plane plane STL - CLE
    2. Take the bus from Cleveland Bus Station to Detroit Bus Stationbus bus
    8h 19m
    $522–958

  7. Fly to Bishop International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Bishop International Airport (FNT)plane plane STL - FNT
    2. Take the bus from Flint to Detroit Bus Stationbus bus
    8h 37m
    $90–462

  8. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from St Louis Bus Station to Chicagobus bus FlixBus N2521
    2. Take the bus from Chicago to Detroit Bus Stationbus bus FlixBus 2552
    14h 49m
    $108–181

St. Louis to Fort Wayne by bus (Greyhound)

Calendar7Weekly Buses
Duration11h 49mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Fort Wayne.ExpandLaunch map view
  • Distance: 476.4 mi
  • Duration: 5h 35m

What companies run services between St. Louis, MO, USA and Fort Wayne, MI, USA?

You can take a bus from St Louis Bus Station to Fort & Livernois via Indianapolis Union Station, Detroit Bus Station, and Fort & Fifth in around 11h 49m. Alternatively, you can take a train from St. Louis to Fort & Campbell via Chicago Union Station, Detroit, Woodward & Baltimore, and Rosa Parks Transit Center - Bay 2 in around 12h 19m.

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