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How to get fromSt. Louis to Graysonby plane, bus, train, bus (Greyhound), car, or train (Amtrak)

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There are 8 ways to get from St. Louis to Grayson by plane, bus, train, bus (Greyhound), car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Tri-State Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Tri-State Airport (HTS)plane plane STL - HTS
    7h 21m
    $152–618

  2. Drive 426.7 mi

    cheapest
    1. Drive from St. Louis to Graysoncar car 426.7 mi
    7h 1m
    $78–113

  3. Bus, train

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train Cardinal
    12h 24m
    $167–310

  4. Bus

    1. Take the bus from St Louis Bus Station to Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus to Ashlandbus bus Bsb 32
    13h 56m

  5. Fly to Blue Grass Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    2. Drive from Lexington-Airport-LEX to Graysoncar car
    7h 15m
    $200–1,030

  6. Fly to Yeager Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Yeager Airport (CRW)plane plane STL - CRW
    2. Take the bus from Charleston to Ashlandbus bus
    9h

  7. Bus, train via Champaign

    1. Take the bus from St Louis Bus Station to Champaign Intermodal Trans Ctrbus bus
    2. Take the bus from Champaign to Indianapolisbus bus
    3. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    14h 24m

  8. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Ashland Amtrak Stationtrain train Cardinal
    18h 14m
    $287–555

Lambert–St. Louis International Airport (STL) to Tri-State Airport (HTS) flights

Calendar15Weekly Planes
Duration6hAverage Duration
Ticket$109Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Grayson.ExpandLaunch map view
  • Distance: 460.9 mi
  • Duration: 7h 21m

What companies run services between St. Louis, MO, USA and Grayson, KY, USA?

American Airlines and Southwest Airlines fly from Lambert–St. Louis International Airport (STL) to Tri-State Airport (HTS) twice daily. Alternatively, you can take a bus from St Louis Bus Station to Grayson via Columbus and Ashland in around 13h 56m.

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