Rome2Rio

How to get fromSt. Louis to Great Lakesby train (Amtrak), bus (Flixbus), car, plane, train, or bus

Find Transport to Great Lakes

See all options

There are 8 ways to get from St. Louis to Great Lakes by train (Amtrak), bus (Flixbus), car, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago OTC to Great Lakestrain train Up-N
    6h 49m
    $98–194

  2. Bus (Flixbus)

    cheapest
    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
    9h 41m
    $59–96

  3. Drive 318.5 mi

    1. Drive from St. Louis to Great Lakescar car 318.5 mi
    5h 31m
    $59–84

  4. Fly Lambert–St. Louis International Airport to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago OTC to Great Lakestrain train
    5h 16m
    $64–384

  5. Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the train from Clybourn to Great Lakestrain train
    5h 33m
    $280–714

  6. Fly Lambert–St. Louis International Airport to General Mitchell International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane plane STL - MKE
    2. Take the bus from Mitchell Airport to Metro Train Station - 13th Avenue and 54th Streetbus bus
    6h 17m
    $492–872

  7. Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport, train

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane plane SPI - ORD
    3. Take the train from Clybourn to Great Lakestrain train
    6h 43m
    $81–321

  8. Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport, train

    1. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    3. Take the train from Clybourn to Great Lakestrain train
    7h 24m
    $132–317

St. Louis to Great Lakes by train, foot, and bus

Calendar38Weekly Services
Duration6h 49mAverage Duration
Ticket$98Cheapest Price
See schedules

Questions & Answers

Map of how to get from St. Louis to Great Lakes.ExpandLaunch map view
  • Distance: 313.5 mi
  • Duration: 6h 49m

What companies run services between St. Louis, MO, USA and Great Lakes, IL, USA?

You can take a train from St. Louis to Great Lakes via Chicago Union Station, Washington & Jefferson, Washington & Canal, and Chicago OTC in around 6h 49m. Alternatively, Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station 4 times a day. Tickets cost $50–85 and the journey takes 6h 5m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

More Questions & Answers