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How to get fromSt. Louis to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

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There are 9 ways to get from St. Louis to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, drive

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 21m
    $132–768

  2. Drive 537.8 mi

    cheapest
    1. Drive from St. Louis to Great Smoky Mountainscar car 537.8 mi
    9h 47m
    $99–142

  3. Bus, drive

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    24h 33m
    $165–321

  4. Fly to Asheville Regional Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Asheville Regional Airport (AVL)plane plane STL - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    7h 16m
    $106–504

  5. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP)plane plane STL - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Great Smoky Mountainscar car
    7h 50m
    $146–738

  6. Fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane STL - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    7h 10m
    $138–658

  7. Fly to Nashville, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    2. Drive from Nashville-Airport-BNA to Great Smoky Mountainscar car
    7h 19m
    $122–668

  8. Bus, drive via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    25h 17m
    $167–336

  9. Bus, train, drive

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    3. Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    25h 33m
    $202–405

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar113Weekly Planes
Duration5h 2mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 477.9 mi
  • Duration: 7h 21m

What companies run services between St. Louis, MO, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from St. Louis to Great Smoky Mountains. However, you can take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from St Louis Bus Station to Great Smoky Mountains via Atlanta Bus Station, Winston Salem(Trans Center), and Asheville, NC in around 24h 33m.

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