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How to get fromSt. Louis to Greenvilleby bus, train, car, plane, or taxi

Find Transport to Greenville

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There are 7 ways to get from St. Louis to Greenville by bus, train, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train, drive

    best
    1. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    2. Take the train from Carbondale to Greenwood Amtrak Stationtrain train
    3. Drive from Greenwood Amtrak Station to Greenvillecar car
    11h 30m
    $124–290

  2. Drive 428.9 mi

    cheapest
    1. Drive from St. Louis to Greenvillecar car 428.9 mi
    7h 20m
    $79–114

  3. Bus, train, drive via Jackson

    1. Take the bus from St Louis Bus Station to Jacksonbus bus
    2. Take the train from Jackson to Yazoo City Amtrak Stationtrain train
    3. Drive from Yazoo City Amtrak Station to Greenvillecar car
    15h 8m
    $103–194

  4. Fly to Bill And Hillary Clinton National Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Bill And Hillary Clinton National Airport (LIT)plane plane STL - LIT
    2. Drive from Bill And Hillary Clinton National Airport (LIT) to Greenvillecar car
    7h 59m
    $114–512

  5. Fly to Monroe Regional Airport, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Monroe Regional Airport (MLU)plane plane STL - MLU
    2. Take the taxi from Monroe Regional Airport (MLU) to Greenvilletaxi taxi
    8h 9m
    $124–578

  6. Fly to Jackson/Vicksburg, train, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Jackson/Vicksburg (JAN)plane plane STL - JAN
    2. Take the train from Jackson to Yazoo City Amtrak Stationtrain train
    3. Drive from Yazoo City Amtrak Station to Greenvillecar car
    8h 26m
    $154–572

  7. Fly to Greenville International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Greenville International Airport (GLH)plane plane STL - GLH
    6h 1m
    $134–578

Lambert–St. Louis International Airport (STL) to Bill And Hillary Clinton National Airport (LIT) flights

Calendar108Weekly Planes
Duration4h 51mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Greenville.ExpandLaunch map view
  • Distance: 491.9 mi
  • Duration: 11h 30m

What companies run services between St. Louis, MO, USA and Greenville, MS, USA?

American Airlines, Key Lime, and Delta fly from Lambert–St. Louis International Airport (STL) to Greenville International Airport (GLH) twice daily.

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